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Author Topic: Nanoparticles Open Doors to Cancer-Fighting CAR T Cells  (Read 1923 times)

Offline Cancer Health Editors

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Nanoparticles Open Doors to Cancer-Fighting CAR T Cells
« on: July 18, 2018, 05:31:31 pm »
In immunotherapy, the CAR T cells that square off against cancerous tumors face quite the Goliath: billions of tumor cells that have recruited healthy cells to help them repel an immune attack. But scientists at Fred Hutchinson Cancer Research Center have developed an inexpensive way to make tumors temporarily vulnerable. In recent work published in Cancer Research, the team used biodegradable liposome-based nanoparticles to carry immune-boosting drugs directly to solid tumors and open a window for CAR T cells to be more effective in preclinical models of breast and brain cancer.

The nanoparticles “are not supposed to replace conventional CAR T-cell therapy,” said Matthias Stephan, MD, PhD, who led the study. Instead, he envisions that “you could use these nanoparticles to precondition the patient, and precondition the tumor, so that your T cells work much better.”



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