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Author Topic: New Gene-Editing Method Could Revolutionize HIV Cure Efforts  (Read 1948 times)

Offline Cancer Health Editors

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Researchers have developed a new cutting-edge way to edit the genome of CD4 immune cells that is faster and more precise than currently used methods, The New York Times reports. While early research into this method has focused on manipulating immune cells to treat cancer or autoimmune disease, scientists believe it could be used to engineer HIV-resistant CD4 cells.

Currently, researchers in the gene-editing field commonly use a deactivated virus, known as a viral vector, to deliver genetic code into cells. In the HIV cure arena, scientists will, for example, draw stem cells that give rise to CD4 cells from an individual with the virus and use viral vectors to insert new genes into those cells that lack a key co-receptor on their surface to which HIV attaches in order to infect the cell. The scientists will then cultivate a large number of such stem cells, reinfuse them into the individual’s body and hope they flourish and populate the immune system with a long-lasting source of immune cells impervious to HIV’s assault.



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