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Author Topic: CRISPR Can Reprogram T Cells to Fight Cancer Without Viruses  (Read 1914 times)

Offline Cancer Health Editors

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A new method using CRISPR gene editing technology could allow scientists to create cancer-fighting T cells more easily, which could potentially increase their availability and reduce their cost, according to a study published this week in Nature.

“This is a rapid, flexible method that can be used to alter, enhance and reprogram T cells so we can give them the specificity we want to destroy cancer, recognize infections or tamp down the excessive immune response seen in autoimmune disease,” lead author Alex Marson, MD, PhD, of the University of California at San Francisco said in a UCSF press release.

Unlike traditional chemotherapy, which directly poisons cancer cells, immunotherapy helps the immune system recognize and fight cancer, usually by boosting the activity of T cells. One method uses a harmless virus to insert new genes into a patient’s T cells to make them express naturally occurring T-cell receptors (TCRs) that can recognize cancer antigens. Another technique, chimeric antigen receptor T-cell therapy, or CAR-T, uses a virus to insert artificial receptors that bind to cancer cells more readily than natural TCRs.



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