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Author Topic: Cancer Cachexia  (Read 148 times)

Offline danialthomas

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Cancer Cachexia
« on: May 08, 2022, 04:37:06 am »
Cancer cachexia (pronounced kuh-KEK-see-uh) is a wasting syndrome caused by cancer. It is a devastating and debilitating condition encoun­tered in more than half of late-stage cancer patients. It is characterized by marked weight loss due to substantial loss of muscle and body fat. It is accompa­nied by a lack of appe­tite, fatigue, decreased strength, and depression. Patients can become so frail and weak that just walking can be difficult.
Cachexia negatively impacts the effectiveness of cancer treatment. It is a strong predictor of poor prognosis and accounts for nearly one-third of all cancer deaths. Sadly, no safe and effective conventional treatment exists. Because of this urgent and unmet medi­cal need in cancer treatment, here are recommendations to counteract cancer cachexia and help rescue patients from its devastating consequences:
· Altered taste: If food does not taste normal (side effect of chemotherapy), consider taking Miracle Fruit. Recommended brand: mberry Miracle Fruit Tablets. Suggested dosage: One tablet before major meals.
· Extra calories: If appetite is good but you need extra calories, consider add­ing 2-3 plant-based, high-calorie protein smoothies daily. See https://www.planthlete.com/.../high-calorie-vegan.../
· Nausea: If nausea is preventing a good appetite, please consider Alvita Organic Ginger-Peppermint tea. Suggested amount: Drink up to 4-5 cups of tea through-out the day. Also consider the amino acid taurine. Suggested dosage: One 1000 mg capsule 3 times daily.
· Systemic inflammation: A major driver of cancer cachexia. If your levels of high-sensitivity C-reactive protein, homocysteine, and/or fibrinogen activity are elevated, besides eating a plant-based diet, consider taking Boswellia & ginger, bromelain, curcumin, nattokinase, specialized pro-resolving mediators, and trimethylglycine.
· Creatine: Combats muscle wasting. Recommend brand: Life Extension Creatine Capsules. Suggested dosage: Two capsules 2-3 times daily.
· Exercise: Combats muscle wasting. Consider the 30-Minute Express Workout 3 days per week at your local Planet Fitness gym. If you do not live near a Planet Fitness, you can do strength training at home using exercise bands. If you are una­ble to participate in strength training, a regular walking program can help.
· Imperatorin: Active component of the herb Angelica dahurica. Combats muscle wasting.Recommended brand: Hawaii Pharm Bai Zhi (Angelica Dahurica) Liquid Herbal Extract. Suggested dosage: 30 drops stirred a glass of water 4 times daily.
· Omega-3 fatty acids: Combats muscle wasting. Recommended brand: Nordic Naturals Ultimate Omega. Suggested dosage: Two capsules twice daily.
· Autophagy inhibition: Autophagy of the tumor stroma is a major contributor to cancer cachexia. Consider the use of over-the-counter loratadine and black seed oil, or prescription hydroxychloroquine and dipyridamole.
· BPC157: This is a custom-compounded, prescription medicinal peptide that combats muscle wasting. It is a self-administered subcutane­ous microinjec­tion. Recommended com­pounding pharmacy: Tailor Made Compounding. Suggested dosage: 250 mcg injected twice daily, 20 days in a row. Repeat every other month.
· Follistatin: This too is a custom-compounded, prescription medicinal pep­tide that combats muscle wasting. It is a self-administered subcutane­ous microinjec­tion. Recommended com­pounding pharmacy: Tailor Made Com­pounding. Suggested dosage: 200 mcg injected daily, 10 days in a row. Repeat monthly.
· Megestrol acetate (Megace®): This is an appetite stimulant. Suggested dos­age: 800 mg orally once a day (20 mL/day).
· Oxytocin: This too is a custom-compounded, prescription medicinal peptide that combats muscle wasting. It is self-administered as a troche which is a small lozenge that dissolves between the cheek and gum over a period of 20-30 minutes. Recom­mended com­pounding pharmacy: Tailor Made Com­pounding Pharmacy. Suggested dosage: 40 IUs 1-2 times daily.

Dr. Daniel Thomas, DO, MS
Mount Dora, Florida

Benoni A, Renzini A, Cavioli G, Adamo S. Neurohypophyseal hormones and skel­etal muscle: a tale of two faces. Eur J Transl Myol. 2020;30(1):8899.
Cole CL, Kleckner IR, Jatoi A, Schwarz EM, Dunne RF. The Role of Systemic Inflammation in Cancer-Associated Muscle Wasting and Rationale for Exercise as a Therapeutic Intervention. JCSM Clin Rep. 2018;3(2):e00065.
de Matos-Neto EM, Lima JD, de Pereira WO, Figuerêdo RG, Riccardi DM, Radloff K, das Neves RX, Camargo RG, Maximiano LF, Tokeshi F, Otoch JP, Goldszmid R, Câmara NO, Trinchieri G, de Alcântara PS, Seelaender M. Systemic Inflammation in Cachexia - Is Tumor Cytokine Expression Profile the Culprit? Front Immunol. 2015 Dec 24;6:629.
Kang EA, Han YM, An JM, Park YJ, Sikiric P, Kim DH, Kwon KA, Kim YJ, Yang D, Tchah H, Hahm KB. BPC157 as Potential Agent Rescuing from Cancer Cachexia. Curr Pharm Des. 2018;24(18):1947-1956.
Linlin Chen, Weiheng Xu, Quanjun Yang, Hong Zhang, Lili Wan, Bo Xin, Junping Zhang, Cheng Guo. Imperatorin alleviates cancer cachexia and prevents muscle wasting via directly inhibiting STAT3. Pharmacological Research. Volume 158, 2020, 104871, ISSN 1043-6618.
Loumaye A, de Barsy M, Nachit M, Lause P, Frateur L, van Maanen A, Trefois P, Gruson D, Thissen JP. Role of Activin A and myostatin in human cancer cachexia. J Clin Endocrinol Metab. 2015 May;100(5):2030-8.
Loumaye A, de Barsy M, Nachit M, Lause P, van Maanen A, Trefois P, Gruson D, Thissen JP. Circulating Activin A predicts survival in cancer patients. J Cachexia Sarcopenia Muscle. 2017 Oct;8(5):768-777.
Martinez-Outschoorn UE, Whitaker-Menezes D, Pavlides S, et al. The autophagic tumor stroma model of cancer or “battery-operated tumor growth”: A simple solu­tion to the autophagy paradox. Cell Cycle. 2010;9(21):4297-4306.
Murphy RA, Mourtzakis M, Mazurak VC. n-3 polyunsaturated fatty acids: the potential role for supplementation in cancer. Current opinion in clinical nutrition and metabolic care. May 2012;15(3):246-251.
Padilha, Camila Souza, Cella, Paola Sanches, Salles, Leo Rodrigues, & Deminice, Rafael. (2017). Oral creatine supplementation attenuates muscle loss caused by limb immobilization: a systematic review. Fisioterapia em Movimento, 30(4), 831-838.
Rautela J, Dagley LF, de Oliveira CC, Schuster IS, Hediyeh-Zadeh S, Delconte RB, Cursons J, Hennessy R, Hutchinson DS, Harrison C, Kita B, Vivier E, Webb AI, Degli-Esposti MA, Davis MJ, Huntington ND, Souza-Fonseca-Guimaraes F. Therapeutic blockade of activin-A improves NK cell function and antitumor immunity. Sci Signal. 2019 Aug 27;12(596):eaat7527.
Wilken MK, Satiroff BA. Pilot study of “miracle fruit” to improve food palatability for patients receiving chemotherapy. Clin J Oncol Nurs. 2012 Oct;16(5):E173-7.

This information is for educational purposes only and not intended or implied to be personal medical advice. That is for your personal physician to provide after he or she accesses and reads each of the references above.
Located in Mount Dora, Florida, Dr. Thomas is one of the most educated, experienced, and innovative physicians in North America. Over the past 30 years, he has helped people throughout the United States and Canada to prevent and overcome disease, improve their health, slow aging, and increase their lifespan. As an active translational researcher, Dr. Thomas has spent over 35,000 hours poring over the latest scientific discoveries and translating max. discoveries into promising theories


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