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Author Topic: Sample protocol for those with stage 1 or 2 Cancer  (Read 656 times)

Offline danialthomas

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Sample protocol for those with stage 1 or 2 Cancer
« on: March 12, 2022, 04:02:32 pm »
Even though I only treat aggressive, metastatic (stage 3 & 4) cancer, many people ask me what I would do to eradicate non-metastatic (stage 1 & 2) cancer, especially if they wanted to see if surgery, chemotherapy, and/or radiation could be avoided. My answer is, I would exploit cancer’s known addiction to iron1 by manipulating iron metabolism in cancer cells and cancer stem cells as follows:

Diet and Lifestyle:
Proper diet and lifestyle lay the foundation to eradicating cancer and preventing its return. To learn more: www.thomashealthblog.com/?p=14640

Oral Protocol:
1. Block cancer energy metabolism by using metformin plus syrosingopine2.
2. Inhibit cancer’s two main antioxidant defense systems (glutathione and thioredoxin reductase) by using curcumin3, fenugreek4, and piperlongumine5.
3. Inhibit carbonic anhydrase 9 (CAIX) to acidify the intracellular pH, disrupt redox homeostasis, and increase vulnerability to ferroptosis by using acetazolamide6.
4. Promote ferroptosis (iron-mediated, pro-oxidative cell death) by using pentoxifylline7,8 and simvastatin9. So as not to neglect other forms of cell death, use berberine10-14 and curcumin15 to promote apoptosis, autophagy, immunogenic cell death, necroptosis, pyroptosis, and paraptosis.
5. Promote removal of tumor-cell debris by using specialized pro-resolving mediators16.
6. Augment the immunomodulatory effects of hyperthermia (see below) by using Ganoderma lucidum (reishi extract)17-20.

Intravenous Protocol:
1. Promote cancer-selective accumulation of iron ions by using low-molecular-weight iron dextran21. This is followed by…
2. Induce ferritin-degrading ferritinophagy by using artesunate22to further promote cancer-selective accumulation of iron ions. This is followed by…
3. Local radiofrequency hyperthermia to selectively “super-heat” iron-loaded cancer tissue up to 47°C with minimal-to-no damage to normal tissue21.

Dr. Daniel Thomas, DO, MS
Mount Dora, Florida

References:

1.   Wang Y, Yu L, Ding J, Chen Y. Iron Metabolism in Cancer. Int J Mol Sci. 2018;20(1):95.
2.   Benjamin D, Robay D, Hindupur SK, Pohlmann J, Colombi M, El-Shemerly MY, Maira SM, Moroni C, Lane HA, Hall MN. Dual Inhibition of the Lactate Transporters MCT1 and MCT4 Is Synthetic Lethal with Metformin due to NAD+ Depletion in Cancer Cells. Cell Rep. 2018 Dec 11;25(11):3047-3058.e4.
3.   Sznarkowska A, Kostecka A, Meller K, Bielawski KP. Inhibition of cancer antioxidant defense by natural compounds. Oncotarget. 2017 Feb 28;8(9):15996-16016.
4.   Cosialls E, El Hage R, Dos Santos L, Gong C, Mehrpour M, Hamaï A. Ferroptosis: Cancer Stem Cells Rely on Iron until "to Die for" It. Cells. 2021 Nov 2;10(11):2981.
5.   Parama D, Rana V, Girisa S, Verma E, Daimary UD, Thakur KK, et al. The promising potential of piperlongumine as an emerging therapeutics for cancer. Explor Target Antitumor Ther. 2021;2:323-54.
6.   Li Z, Jiang L, Toyokuni S. Role of carbonic anhydrases in ferroptosis-resistance. Arch Biochem Biophys. 2020 Aug 15;689:108440.
7.   Fuhrmann DC, Mondorf A, Beifuß J, Jung M, Brüne B. Hypoxia inhibits ferritinophagy, increases mitochondrial ferritin, and protects from ferroptosis. Redox Biol. 2020 Sep;36:101670.
8.   Lee I, Boucher Y, Demhartner TJ, Jain RK. Changes in tumour blood flow, oxygenation and interstitial fluid pressure induced by pentoxifylline. Br J Cancer. 1994;69(3):492-496.
9.   Jiang W, Hu JW, He XR, Jin WL, He XY. Statins: a repurposed drug to fight cancer. J Exp Clin Cancer Res. 2021 Jul 24;40(1):241.
10.   Yip NK, Ho WS. Berberine induces apoptosis via the mitochondrial pathway in liver cancer cells. Oncol Rep. 2013 Sep;30(3):1107-12.
11.   Liu J, Liu P, Xu T, et al. Berberine Induces Autophagic Cell Death in Acute Lymphoblastic Leukemia by Inactivating AKT/mTORC1 Signaling. Drug Des Devel Ther. 2020;14:1813-1823.
12.   Wang Y, Liu Y, Du X, Ma H, Yao J. The Anti-Cancer Mechanisms of Berberine: A Review. Cancer Manag Res. 2020;12:695-702.
13.   Liu L, Fan J, Ai G, Liu J, Luo N, Li C, Cheng Z. Berberine in combination with cisplatin induces necroptosis and apoptosis in ovarian cancer cells. Biol Res. 2019 Jul 18;52(1):37.
14.   Zhang C, Sheng J, Li G, et al. Effects of Berberine and Its Derivatives on Cancer: A Systems Pharmacology Review. Front Pharmacol. 2020;10:1461.
15.   Lee D, Kim IY, Saha S, Choi KS. Paraptosis in the anti-cancer arsenal of natural products. Pharmacol Ther. 2016 Jun;162:120-33.
16.   Zhang Q, Zhu B, Li Y. Resolution of Cancer-Promoting Inflammation: A New Approach for Anticancer Therapy. Front Immunol. 2017 Feb 2;8:71.
17.   Chang CJ, Chen YY, Lu CC, Lin CS, Martel J, Tsai SH, Ko YF, Huang TT, Ojcius DM, Young JD, Lai HC. Ganoderma lucidum stimulates NK cell cytotoxicity by inducing NKG2D/NCR activation and secretion of perforin and granulysin. Innate Immun. 2014 Apr;20(3):301-11.
18.   Mojadadi, Shafi et al. Immunomodulatory Effects of Ganoderma lucidum (W. Curt.:Fr.) P. Karst. (Aphyllophoromycetideae) on CD4+/CD8+ Tumor Infiltrating Lymphocytes in Breast-Cancer-Bearing Mice. International Journal of Medicinal Mushrooms8 (2006): 315-320.
19.   Song M, Li ZH, Gu HS, Tang RY, Zhang R, Zhu YL, Liu JL, Zhang JJ, Wang LY. Ganoderma lucidum Spore Polysaccharide Inhibits the Growth of Hepatocellular Carcinoma Cells by Altering Macrophage Polarity and Induction of Apoptosis. J Immunol Res. 2021 Mar 5;2021:6696606.
20.   Xia QH, Lu CT, Tong MQ, et al. Ganoderma Lucidum Polysaccharides Enhance the Abscopal Effect of Photothermal Therapy in Hepatoma-Bearing Mice Through Immunomodulatory, Anti-Proliferative, Pro-Apoptotic and Anti-Angiogenic. Front Pharmacol. 2021;12:648708.
21.   Chung, HJ., Kim, HJ. & Hong, ST. Iron-dextran as a thermosensitizer in radiofrequency hyperthermia for cancer treatment. Appl Biol Chem 62, 24 (2019).
22.   Chen G, Guo G, Zhou X, Chen H. Potential mechanism of ferroptosis in pancreatic cancer. Oncol Lett. 2020 Jan;19(1):579-587.

Disclaimer:

This information is for educational purposes only and is not intended or implied to be a substitute for professional medical advice, diagnosis, treatment, and monitor¬ing by your doctor. Therefore, Dr. Thomas cannot answer any questions regarding appropriateness in your situation nor give treatment advice. That is for your doctor to determine after he or she diligently reads each of the references above.
Located in Mount Dora, Florida, Dr. Thomas is one of the most educated, experienced, and innovative physicians in North America. Over the past 30 years, he has helped people throughout the United States and Canada to prevent and overcome disease, improve their health, slow aging, and increase their lifespan. As an active translational researcher, Dr. Thomas has spent over 35,000 hours poring over the latest scientific discoveries and translating max. discoveries into promising theories

 


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