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Author Topic: Sorting Cancers by ‘Immune Archetypes’ May Offer New Approach For Precision Immu  (Read 668 times)

Offline iana5252

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Using data from over 300 patient tumors, UC San Francisco researchers have described 12 classes of “immune archetypes” to classify cancer tumors. Their findings, published this week in CELL, reveal that cancers from different parts of the body are immunologically similar to one another. These classifications provide unique strategies for enhancing each patient’s choice of cancer immunotherapies.

The UCSF researchers, led by first co-authors Alexis Combes, PhD, and Bushra Samad, MS, and senior author, Max Krummel, PhD, obtained tumor specimens from 78 UCSF clinicians, and surveyed 364 tumors biopsies from patients and categorized them into groups based on their immune microenvironment. Their findings offer a new way of looking at cancer immunotherapy that matches the immune environment around the tumor and points the way to personalized immunotherapies.

“This is a new framework for how to look at cancer patients,” said Combes, director of the D2B CoLab and incoming assistant professor in the Department of Pathology at UCSF. “This work will help clinicians find the right biology to target and avoid targeting cells that aren’t present in the tumor.”

Read more...
https://www.cancerhealth.com/article/sorting-cancers-by-immune-archetypes-may-offer-new-approach-precision-immunotherapy

 


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