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Author Topic: Next-Generation Cancer Treatment  (Read 913 times)

Offline danialthomas

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Next-Generation Cancer Treatment
« on: January 16, 2022, 05:42:22 pm »
For those who fear chemotherapy because of its side effects or have become discouraged by chemotherapy because it stopped working, the protocol below should be considered. It builds upon my successes over the past 30+ years along with the recent successes of an overseas colleague of mine who has been combining high-dose vitamin C with low-dose chemotherapy and achieving rather impressive results. As a result of our co-collaboration, we believe that a combined approach will be even more effective.

Due to the low dose of chemotherapy drugs, treatment is generally well tolerated with most patients experiencing no severe side effects. The main side effect is nausea, and this is minimized by using ondansetron (Zofran).

Once-a-week, in-office treatment:

• Intravenous high-dose vitamin C plus doxycycline, azithromycin, and solamargine, along with hyperthermia to heat tumor tissue to 42°C. This is immediately followed by…
• Intravenous chemotherapy combining 3-5 synergistic drugs used for the cancer type at 1/3 to 1/5 the normal dose. This is combined with intravenous curcumin and additional hyperthermia at 42°C.
• The following morning, we do hyperthermia only. This time, heating tumor tissue to 45°C.

Supporting oral medications and supplements:

• Acetazolamide
• Aspirin
• Berberine
• Bromelain
• Fisetin
• Ivermectin
• Metformin
• Nattokinase
• Pentoxifylline
• Piperlongumine
• Reishi mushroom wall-broken spore powder
• Specialized pro-resolving mediators
• Syrosingopine

The scientific rationale for the protocol is broken down into these seven components:

1. Inhibit cancer metabolism (“starve” cancer): Metformin and syrosingopine1
2. Promote chemosensitivity and chemoprotection, and inhibit multi-drug resistance: Ivermectin2, pentoxifylline3, intravenous curcumin4,5
3. Overcome barriers to treatment by targeting conditions in the tumor microenvironment that impede intratumoral distribution of anticancer compounds and promote immune evasion:

• Hypoperfusion and hypoxia: Pentoxifylline6, hyperthermia at 42°C7
• Elevated tumor fluid pressure: Pentoxifylline6, hyperthermia at 42°C8
• Extracellular acidification: Metformin and syrosingopine1, acetazolamide9
• Inflammation: Berberine10, specialized pro-resolving mediators11
• Fibrin clots: Bromelain12, nattokinase13

4. Kill proliferating (active) cancer cells by inducing six different forms of cell death:

• Apoptosis: Berberine14, reishi extract15, intravenous vitamin C and low-dose chemotherapy15 with solamargine17 and hyperthermia7
• Autophagy: Berberine18, piperlongumine19
• Ferroptosis: Acetazolamide20,21, piperlongumine22
• Immunogenic cell death: Berberine10, piperlongumine23, reishi extract24-26, intravenous solamargine17, hyperthermia at 45°C27
• Necroptosis: Berberine28, hyperthermia at 45°C7
• Pyroptosis: Metformin29, berberine29

5. Kill senescent (dormant) cancer cells: Fisetin31, piperlongumine32, intravenous solamargine17
6. Eradicate cancer stem cells: Intravenous vitamin C plus azithromycin and doxycycline33
7. Promote phagocytic removal of tumor debris: Aspirin34, specialized pro-resolving mediators11

Dr. Daniel Thomas, DO, MS
Mount Dora, Florida

References:

1. Benjamin D, Robay D, Hindupur SK, Pohlmann J, Colombi M, El-Shemerly MY, Maira SM, Moroni C, Lane HA, Hall MN. Dual Inhibition of the Lactate Transporters MCT1 and MCT4 Is Synthetic Lethal with Metformin due to NAD+ Depletion in Cancer Cells. Cell Rep. 2018 Dec 11;25(11):3047-3058.e4.
2. Jiang L, Wang P, Sun YJ, Wu YJ. Ivermectin reverses the drug resistance in cancer cells through EGFR/ERK/Akt/NF-κB pathway. J Exp Clin Cancer Res. 2019 Jun 18;38(1):265.
3. Barancik M, Bohacova V, Gibalova L, Sedlak J, Sulova Z, Breier A. Potentiation of anticancer drugs: effects of pentoxifylline on neoplastic cells. Int J Mol Sci. 2012;13(1):369-382.
4. Tang XQ, Bi H, Feng JQ, Cao JG. Effect of curcumin on multidrug resistance in resistant human gastric carcinoma cell line SGC7901/VCR. Acta Pharmacol Sin. 2005 Aug;26(8):1009-16.
5. Liu Z, Huang P, Law S, Tian H, Leung W, Xu C. Preventive Effect of Curcumin Against Chemotherapy-Induced Side-Effects. Front Pharmacol. 2018;9:1374.
6. Lee I, Boucher Y, Demhartner TJ, Jain RK. Changes in tumour blood flow, oxygenation and interstitial fluid pressure induced by pentoxifylline. Br J Cancer. 1994;69(3):492-496.
7. Hannon, G., Tansi, F.L., Hilger, I. and Prina-Mello, A. (2021), The Effects of Localized Heat on the Hallmarks of Cancer. Adv. Therap., 4: 2000267.
8. Leunig M, Goetz AE, Dellian M, Zetterer G, Gamarra F, Jain RK, Messmer K. Interstitial fluid pressure in solid tumors following hyperthermia: possible correlation with therapeutic response. Cancer Res. 1992 Jan 15;52(2):487-90.
9. Lee SH, McIntyre D, Honess D, Hulikova A, Pacheco-Torres J, Cerdán S, Swietach P, Harris AL, Griffiths JR. Carbonic anhydrase IX is a pH-stat that sets an acidic tumour extracellular pH in vivo. Br J Cancer. 2018 Aug;119(5):622-630.
10. Wang Y, Liu Y, Du X, Ma H, Yao J. The Anti-Cancer Mechanisms of Berberine: A Review. Cancer Manag Res. 2020;12:695-702.
11. Zhang Q, Zhu B, Li Y. Resolution of Cancer-Promoting Inflammation: A New Approach for Anticancer Therapy. Front Immunol. 2017 Feb 2;8:71.
12. Pavan R, Jain S, Shraddha, Kumar A. Properties and therapeutic application of bromelain: a review. Biotechnol Res Int. 2012;2012:976203.
13. Altaf F, Wu S, Kasim V. Role of Fibrinolytic Enzymes in Anti-Thrombosis Therapy. Front Mol Biosci. 2021;8:680397.
14. Yip NK, Ho WS. Berberine induces apoptosis via the mitochondrial pathway in liver cancer cells. Oncol Rep. 2013 Sep;30(3):1107-12.
15. Wu X, Jiang L, Zhang Z, He Y, Teng Y, Li J, Yuan S, Pan Y, Liang H, Yang H, Zhou P. Pancreatic cancer cell apoptosis is induced by a proteoglycan extracted from Ganoderma lucidum. Oncol Lett. 2021 Jan;21(1):34.
16. Ong CP. High Dose Vitamin C and Low Dose Chemo Treatment. J Cancer Sci. 2018;5(1): 4.
17. Cham, B. (2017) Solasodine, Solamargine and Mixtures of Solasodine Rhamnosides: Pathway to Expansive Clinical Anticancer Therapies. International Journal of Clinical Medicine, 8, 692-713.
18. Liu J, Liu P, Xu T, et al. Berberine Induces Autophagic Cell Death in Acute Lymphoblastic Leukemia by Inactivating AKT/mTORC1 Signaling. Drug Des Devel Ther. 2020;14:1813-1823.
19. Wang Y, Wang JW, Xiao X, Shan Y, Xue B, Jiang G, He Q, Chen J, Xu HG, Zhao RX, Werle KD, Cui R, Liang J, Li YL, Xu ZX. Piperlongumine induces autophagy by targeting p38 signaling. Cell Death Dis. 2013 Oct 3;4(10):e824.
20. Chafe S, Vizeacoumar F, Venkateswaran G, Nemirovsky O, Awrey S, et.al. Genome-wide synthetic lethal screen unveils novel CAIX-NFS1/xCT axis as a targetable vulnerability in hypoxic solid tumors. Science Advances. 27 Aug 2021: Vol. 7, No. 35, eabj0364.
21. Said HM, Hagemann C, Carta F, Katzer A, Polat B, Staab A, Scozzafava A, Anacker J, Vince GH, Flentje M, Supuran CT. Hypoxia induced CA9 inhibitory targeting by two different sulfonamide derivatives including acetazolamide in human glioblastoma. Bioorg Med Chem. 2013 Jul 1;21(13):3949-57.
22. Yamaguchi Y, Kasukabe T, Kumakura S. Piperlongumine rapidly induces the death of human pancreatic cancer cells mainly through the induction of ferroptosis. Int J Oncol. 2018 Mar;52(3):1011-1022.
23. Afolabi LO, Bi J, Chen L, Wan X. A natural product, Piperlongumine (PL), increases tumor cells sensitivity to NK cell killing. Int Immunopharmacol. 2021 Jul;96:107658.
24. Chang CJ, Chen YY, Lu CC, Lin CS, Martel J, Tsai SH, Ko YF, Huang TT, Ojcius DM, Young JD, Lai HC. Ganoderma lucidum stimulates NK cell cytotoxicity by inducing NKG2D/NCR activation and secretion of perforin and granulysin. Innate Immun. 2014 Apr;20(3):301-11.
25. Mojadadi, Shafi et al. Immunomodulatory Effects of Ganoderma lucidum (W. Curt.:Fr.) P. Karst. (Aphyllophoromycetideae) on CD4+/CD8+ Tumor Infiltrating Lymphocytes in Breast-Cancer-Bearing Mice. International Journal of Medicinal Mushrooms8 (2006): 315-320.
26. Song M, Li ZH, Gu HS, Tang RY, Zhang R, Zhu YL, Liu JL, Zhang JJ, Wang LY. Ganoderma lucidum Spore Polysaccharide Inhibits the Growth of Hepatocellular Carcinoma Cells by Altering Macrophage Polarity and Induction of Apoptosis. J Immunol Res. 2021 Mar 5;2021:6696606.
27. Toraya-Brown S, Fiering S. Local tumour hyperthermia as immunotherapy for metastatic cancer. Int J Hyperthermia. 2014;30(8):531-539.
28. Liu L, Fan J, Ai G, Liu J, Luo N, Li C, Cheng Z. Berberine in combination with cisplatin induces necroptosis and apoptosis in ovarian cancer cells. Biol Res. 2019 Jul 18;52(1):37.
29. Wang L, Qin X, Liang J, Ge P. Induction of Pyroptosis: A Promising Strategy for Cancer Treatment. Front Oncol. 2021 Feb 26;11:635774.
30. Zhang C, Sheng J, Li G, et al. Effects of Berberine and Its Derivatives on Cancer: A Systems Pharmacology Review. Front Pharmacol. 2020;10:1461.
31. Yousefzadeh MJ, Zhu Y, McGowan SJ, Angelini L, Fuhrmann-Stroissnigg H, Xu M, Ling YY, Melos KI, Pirtskhalava T, Inman CL, McGuckian C, Wade EA, Kato JI, Grassi D, Wentworth M, Burd CE, Arriaga EA, Ladiges WL, Tchkonia T, Kirkland JL, Robbins PD, Niedernhofer LJ. Fisetin is a senotherapeutic that extends health and lifespan. EBioMedicine. 2018 Oct;36:18-28.
32. Wang Y, Chang J, Liu X, et al. Discovery of piperlongumine as a potential novel lead for the development of senolytic agents. Aging (Albany NY). 2016;8(11):2915-2926.
33. Fiorillo M, Tóth F, Sotgia F, Lisanti MP. Doxycycline, Azithromycin and Vitamin C (DAV): A potent combination therapy for targeting mitochondria and eradicating cancer stem cells (CSCs). Aging (Albany NY). 2019 Apr 19;11(8):2202-2216.
34. Dalli J, Winkler JW, Colas RA, Arnardottir H, Cheng CY, Chiang N, Petasis NA, Serhan CN. Resolvin D3 and aspirin-triggered resolvin D3 are potent immunoresolvents. Chem Biol. 2013 Feb 21;20(2):188-201.

Disclaimer:

This information is for educational purposes only and not intended or implied to be a substitute for professional medical advice, diagnosis, treatment, and monitoring by your doctor. Therefore, Dr. Thomas cannot answer questions regarding appropriateness in your situation nor give treatment advice. That is for your doctor to determine after he or she carefully studies each of the references above.
Located in Mount Dora, Florida, Dr. Thomas is one of the most educated, experienced, and innovative physicians in North America. Over the past 30 years, he has helped people throughout the United States and Canada to prevent and overcome disease, improve their health, slow aging, and increase their lifespan. As an active translational researcher, Dr. Thomas has spent over 35,000 hours poring over the latest scientific discoveries and translating max. discoveries into promising theories

 


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