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Author Topic: Eggplant To The Rescue  (Read 280 times)

Offline danialthomas

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Eggplant To The Rescue
« on: November 18, 2021, 11:29:20 am »
This will be my last posting for a while. I will be extra busy as I am going back to “school” by doing a fellowship in Metabolic Cardiology under the direction of Drs. Stephen Sinatra and Mark Houston. The focus of my practice will still be metabolic medicine and integrative cancer therapeutics, but because we are dependent on blood flow for the delivery of most medical interventions, the valuable knowledge I will gain in the cardiology fellowship will help improve our cancer treatment outcomes even further.

Many of the patients that I see have aggressive, late-stage cancer that is responding poorly or has stopped responding to conventional treatment, including trial drugs. These patients have an exceedingly strong desire to live and are not mentally ready to throw in the towel and call Hospice. Therefore, I must continually pore over the latest scientific literature in search of potentially life-saving therapeutic strategies to offer these patients. In previous postings, I have written about many of these strategies. Two medicinal plant compounds that currently have me intrigued and look promising are solamargine and solasonine.

Found in eggplant, solamargine and solasonine appear to have the fol¬lowing unique and highly desirable characteristics:

• Rapidly induces cell cycle arrest and apoptosis (cell death) in a wide variety of malignancies.
• Greater cytotoxic effects on cancer cells compared to many standard chemo-therapy drugs with negligible effect on normal cells.
• Ability to treat tumors that have become multi-drug resistant.
• Inhibits the ability of tumors to metastasize by blocking epithelial-mesenchymal transition (EMT).
• Targets active and quiescent (dormant) cancer cells, as well as cancer stem cells. Chemotherapy is designed to affect rapidly proliferating cells. To resist the effects of chemotherapy, cancer cells can stop proliferating and go into a state of dormancy, and later “wake up” and begin proliferating again.
• May stimulate lasting immunity against cancer.

Solamargine and solasonine are not commercially available at any retail or com-pounding pharmacy. Because of this, we had medicinal chemists custom synthesize these compounds for us from scratch and purify them to pharmaceutical levels. Starting next year, in select patients, we will administer a 50/50 mix of solamargine and solasonine intravenously to assure full bioavailability and prevent possible biochemical alteration by stomach acids and gut bacteria from oral administration. We will also apply administer hyperthermia to change the characteristics of the cancer cells and sensitize them to the effects of solamargine and solasonine and increase tumor blood flow to deliver more of the compounds into the tumors.

Dr. Daniel Thomas, DO, MS
Mount Dora, Florida

For more information:
Alshaibi HF, Al-Shehri B, Hassan B, Al-Zahrani R, Assiss T. Modulated Electrohyperthermia: A New Hope for Cancer Patients. Biomed Res Int. 2020 Nov 13;2020:8814878.
Cham, B. (2013) Drug therapy: Solamargine and other solasodine rhamnosyl gly¬cosides as anticancer agents. Modern Chemotherapy, 2, 33-49.
Cham, B.E. (2017) Solasodine, Solamargine and Mixtures of Solasodine Rhamno¬sides: Pathway to Expansive Clinical Anticancer Therapies. International Journal of Clinical Medicine, 8, 692-713.
Mayank, Jaitak V. Molecular docking study of natural alkaloids as multi-targeted hedgehog pathway inhibitors in cancer stem cell therapy. Comput Biol Chem. 2016 Jun;62:145-54.
S.S.S. Al Sinani, E.A. Eltayeb. The steroidal glycoalkaloids solamargine and solasonine in Solanum plants. South African Journal of Botany, Vol. 112, 2017, 253-269.

Disclaimer:
This information is for educational purposes only and not intended or implied to be a substitute for professional medical advice, diagnosis, treatment, and monitoring by your doctor. Therefore, I cannot answer questions regarding appropriateness in your situation, nor give dosages or treatment advice. That is for your personal doctor to determine after he or she carefully studies the references above.
Located in Mount Dora, Florida, Dr. Thomas is one of the most educated, experienced, and innovative physicians in North America. Over the past 30 years, he has helped people throughout the United States and Canada to prevent and overcome disease, improve their health, slow aging, and increase their lifespan. As an active translational researcher, Dr. Thomas has spent over 35,000 hours poring over the latest scientific discoveries and translating max. discoveries into promising theories

 


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