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Author Topic: Novel Cancer Approach Discovered By Scientists  (Read 217 times)

Offline danialthomas

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Novel Cancer Approach Discovered By Scientists
« on: October 19, 2021, 04:53:36 pm »
Having devoted a major portion of my 34-year medical career to reading the scientific literature, I have gotten to know some of the world’s leading oncobiologists. Sometimes I come across scientists whose findings from animal studies look so promising and so compelling, they cry out to be implemented in humans, especially when a stage-4 cancer patient is running out of options. One such finding has to do with senescence cancer cells and the argument against low-dose chemotherapy.

Not all cancer cells can be forced into apoptosis (programmed cell death) when treated with chemotherapy. Instead of dying outright, many cancer cells simply stop proliferating, come to a standstill, and enter a senescent or dormant-like state. This is called senescence-associated growth arrest (SAGA), and while it sounds good, it is accompanied by something bad called senescence-associated secretory phenotype (SASP) in which the senescent cancer cells secrete copious amounts of pro-inflammatory molecules, protein-degrading compounds, and cancer-promoting growth factors. These harmful compounds can stimulate cancer stem cells which can repopulate the tumor with new cancer cells.

Many chemotherapy drugs act as “senogenic” agents, meaning, they induce senescence in cancer cells. However, when combined with “senolytic” drugs, meaning, repurposed drugs shown to eradicate senescent cells, scientists found this to be a novel and powerful “one-two punch” to quickly eradicate cancer cells. In other words, using chemotherapy to create senescent cancer cells, then killing them using senolytic drugs. Two such prescription senolytic drugs that are readily available are dasatinib and digoxin. Interestingly, the scientists found that only standard doses of chemotherapy were able to induce senescence in cancer cells. When lower doses of chemotherapy were used, they were unable to induce senescence. And without the presence of senescent cancer cells, senolytic drugs have no target to treat and are therefore unable to achieve the desired result, that is, the death of cancer cells.

Dr. Daniel Thomas, DO, MS
Mount Dora, Florida

For more information:

Kirkland JL, Tchkonia T. Senolytic drugs: from discovery to translation. J Intern Med. 2020 Nov;288(5):518-536.
Triana-Martínez F, Picallos-Rabina P, Da Silva-Álvarez S, Pietrocola F, Llanos S, Rodilla V, Soprano E, Pedrosa P, Ferreirós A, Barradas M, Hernández-González F, Lalinde M, Prats N, Bernadó C, González P, Gómez M, Ikonomopoulou MP, Fernández-Marcos PJ, García-Caballero T, Del Pino P, Arribas J, Vidal A, González-Barcia M, Serrano M, Loza MI, Domínguez E, Collado M. Identification and characterization of Cardiac Glycosides as senolytic compounds. Nat Commun. 2019 Oct 21;10(1):4731.

Disclaimer:

This information is for educational purposes only and not intended or implied to be a substitute for professional medical advice, diagnosis, treatment, and monitoring by your doctor. Therefore, I cannot answer questions regarding appropriateness in your situation nor give treatment advice. That is for your doctor to determine after he or she carefully studies the references above. Your doctor also needs to be very familiar with the narrow therapeutic index of digoxin.
Located in Mount Dora, Florida, Dr. Thomas is one of the most educated, experienced, and innovative physicians in North America. Over the past 30 years, he has helped people throughout the United States and Canada to prevent and overcome disease, improve their health, slow aging, and increase their lifespan. As an active translational researcher, Dr. Thomas has spent over 35,000 hours poring over the latest scientific discoveries and translating max. discoveries into promising theories

 


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