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Author Topic: Iron Removal Enhances Intravenous Vitamin C-Induced Apoptosis Of Cancer Cells  (Read 430 times)

Offline danialthomas

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High blood levels of the extracellular iron-storage protein called ferritin correlate with aggressive disease and poorer clinical outcomes in cancer patients. Excess extracellular iron has been found to diminish the anti-cancer effects of intravenous vitamin C (IVC). Based on this, administering IVC without considering ferritin levels is ill-advised. Excess extracellular iron decreases the intracellular uptake of vitamin C and IVC-induced production of cancer-killing, pro-oxidative hydrogen peroxide. Removal of extracellular iron using the iron-chelating drug Deferasirox was shown to improve the anti-cancer effects of IVC by promoting intracellular uptake of vitamin C and IVC-induced production of hydrogen peroxide.

Dr. Daniel Thomas, DO, MS
Mount Dora, Florida

Reference:
Tsuma-Kaneko, M., Sawanobori, M., Kawakami, S. et al. Iron removal enhances vitamin C-induced apoptosis and growth inhibition of K-562 leukemic cells. Sci Rep 8, 17377 (2018).

Disclaimer:
This information is for educational purposes only. It is not intended or implied to be a substitute for professional medical advice, diagnosis, treatment, and monitoring by your personal physician. Therefore, I cannot comment as to appropriateness in your situation, nor give dosages or treatment guidelines. That is for your personal physician to determine after studying the reference above
Located in Mount Dora, Florida, Dr. Thomas is one of the most educated, experienced, and innovative physicians in North America. Over the past 30 years, he has helped people throughout the United States and Canada to prevent and overcome disease, improve their health, slow aging, and increase their lifespan. As an active translational researcher, Dr. Thomas has spent over 35,000 hours poring over the latest scientific discoveries and translating max. discoveries into promising theories

 


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