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Author Topic: Cancer Cachexia  (Read 361 times)

Offline danialthomas

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Cancer Cachexia
« on: March 18, 2021, 05:29:45 pm »
Cancer cachexia (pronounced kuh-KEK-see-uh) is a complex metabolic wasting syndrome caused by cancer. It is a devastating and debilitating condition encountered in more than half of late-stage cancer patients. It is characterized by marked weight loss due to a dramatic loss of muscle and body fat. It is accompanied by a lack of appetite, fatigue, decreased strength, and depression. Patients can become so frail and weak that just walking can be difficult.

Cachexia compromises the effectiveness of cancer treatment, is a strong predictor of poor prognosis and accounts for nearly one-third of all cancer deaths. Sadly, no safe and effective conventional treatment exists. Because of this urgent and unmet medical need in cancer treatment, here is what I use to counteract cancer cachexia and help rescue patients from its devastating consequences:

• Altered taste: If food does not taste normal (side effect of chemotherapy), consider taking Miracle Fruit.
• Appetite stimulant: If appetite is poor, consider asking your doctor to pre-scribe megestrol acetate (Megace®) oral suspension.
• Extra calories: If appetite is good but you need extra calories, consider adding 2-3 plant-based, high-calorie protein smoothies daily.
• Nausea: If nausea is preventing a good appetite, consider the use of taurine along with ginger/peppermint tea.
• Systemic inflammation: A major driver of cancer cachexia. If your levels of high-sensitivity C-reactive protein, homocysteine, and/or fibrinogen activity are elevated, there are natural compounds that can help lower them.
• Creatine: Combats muscle wasting.
• Exercise: Combats muscle wasting.
• Imperatorin: Active component of the herb Angelica dahurica. Combats muscle wasting.
• Omega-3 fatty acids: Combats muscle wasting.
• Autophagy inhibition: Autophagy of the tumor is a major contributor to cancer cachexia. Consider the use of over-the-counter loratadine and black seed oil, or prescription hydroxychloroquine and dipyridamole.
• BPC157: This is a medicinal peptide that combats muscle wasting.
• Follistatin: This also is a medicinal peptide that combats muscle wasting.
• Oxytocin: This too is a medicinal peptide that combats muscle wasting.

Please note that this information for educational purposes only. It is not intended or implied to be a substitute for professional medical advice, diagnosis, treatment, and monitoring by your personal physician. Therefore, I cannot give dosages for the above-mentioned supplements and medications. That is for your personal physician to determine.

Dr. Daniel Thomas, DO, MS
Mount Dora, Florida


References:

Benoni A, Renzini A, Cavioli G, Adamo S. Neurohypophyseal hormones and skeletal muscle: a tale of two faces. Eur J Transl Myol. 2020;30(1):8899.
Cole CL, Kleckner IR, Jatoi A, Schwarz EM, Dunne RF. The Role of Systemic Inflammation in Cancer-Associated Muscle Wasting and Rationale for Exercise as a Therapeutic Intervention. JCSM Clin Rep. 2018;3(2):e00065.
de Matos-Neto EM, Lima JD, de Pereira WO, Figuerêdo RG, Riccardi DM, Radloff K, das Neves RX, Camargo RG, Maximiano LF, Tokeshi F, Otoch JP, Goldszmid R, Câmara NO, Trinchieri G, de Alcântara PS, Seelaender M. Systemic Inflammation in Cachexia - Is Tumor Cytokine Expression Profile the Culprit? Front Immunol. 2015 Dec 24;6:629.
Kang EA, Han YM, An JM, Park YJ, Sikiric P, Kim DH, Kwon KA, Kim YJ, Yang D, Tchah H, Hahm KB. BPC157 as Potential Agent Rescuing from Cancer Cachexia. Curr Pharm Des. 2018;24(18):1947-1956.
Linlin Chen, Weiheng Xu, Quanjun Yang, Hong Zhang, Lili Wan, Bo Xin, Junping Zhang, Cheng Guo. Imperatorin alleviates cancer cachexia and prevents muscle wasting via directly inhibiting STAT3. Pharmacological Research. Volume 158, 2020, 104871, ISSN 1043-6618.
Loumaye A, de Barsy M, Nachit M, Lause P, Frateur L, van Maanen A, Trefois P, Gruson D, Thissen JP. Role of Activin A and myostatin in human cancer cachexia. J Clin Endocrinol Metab. 2015 May;100(5):2030-8.
Loumaye A, de Barsy M, Nachit M, Lause P, van Maanen A, Trefois P, Gruson D, Thissen JP. Circulating Activin A predicts survival in cancer patients. J Cachexia Sarcopenia Muscle. 2017 Oct;8(5):768-777.
Martinez-Outschoorn UE, Whitaker-Menezes D, Pavlides S, et al. The autophagic tumor stroma model of cancer or “battery-operated tumor growth”: A simple solution to the autophagy paradox. Cell Cycle. 2010;9(21):4297-4306.
Murphy RA, Mourtzakis M, Mazurak VC. n-3 polyunsaturated fatty acids: the potential role for supplementation in cancer. Current opinion in clinical nutrition and metabolic care. May 2012;15(3):246-251.
Padilha, Camila Souza, Cella, Paola Sanches, Salles, Leo Rodrigues, & Deminice, Rafael. (2017). Oral creatine supplementation attenuates muscle loss caused by limb immobilization: a systematic review. Fisioterapia em Movimento, 30(4), 831-838.
Rautela J, Dagley LF, de Oliveira CC, Schuster IS, Hediyeh-Zadeh S, Delconte RB, Cursons J, Hennessy R, Hutchinson DS, Harrison C, Kita B, Vivier E, Webb AI, Degli-Esposti MA, Davis MJ, Huntington ND, Souza-Fonseca-Guimaraes F. Therapeutic blockade of activin-A improves NK cell function and antitumor immunity. Sci Signal. 2019 Aug 27;12(596):eaat7527.
Wilken MK, Satiroff BA. Pilot study of “miracle fruit” to improve food palatability for patients receiving chemotherapy. Clin J Oncol Nurs. 2012 Oct;16(5):E173-7.
Located in Mount Dora, Florida, Dr. Thomas is one of the most educated, experienced, and innovative physicians in North America. Over the past 30 years, he has helped people throughout the United States and Canada to prevent and overcome disease, improve their health, slow aging, and increase their lifespan. As an active translational researcher, Dr. Thomas has spent over 35,000 hours poring over the latest scientific discoveries and translating max. discoveries into promising theories

 


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