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Author Topic: Overcoming Obstacles To Tumor Drug Delivery  (Read 1654 times)

Offline danialthomas

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Overcoming Obstacles To Tumor Drug Delivery
« on: October 11, 2020, 04:42:13 pm »
Whether administered orally or intravenously, every drug and every natural compound that is used to treat cancer must reach the targeted cells in the tumor environment at adequate concentrations to exert their intended cell-killing effects. Any well-intentioned treatment may be misguided and doomed to failure if you do not overcome conditions that exist in the tumor microenvironment that can prevent adequate delivery of cancer-killing substances.

Compared to normal (functional) blood vessels, tumor blood vessels are highly dysfunctional. The structure of tumor vessels is irregular and disorganized; blood flow is inadequate and turbulent; and the vessel walls are highly porous and leaky. Combined with a lack of lymphatic drainage and the presence of inflammatory molecules in the tumor microenvironment, this leads to edema (accumulation of fluid) in the interstitium or extracellular space (spaces around the tumor cells). This results in an increase in the tumor interstitial fluid pressure that exceeds the fluid pressure in tumor blood vessels. The resultant pressure gradient prevents adequate amounts of cancer-killing substances from exiting the tumor blood vessels into the interstitium and onto the cancer cells. Increased tumor interstitial fluid pressure is the first obstacle that must be overcome.

The second obstacle that must be overcome is the density of the tumor microenvironment. The journey that a drug must take to reach cancer cells is akin to making your way through a maze. If a drug has been able to cross the vessel wall, it must now make the difficult journey through the tumor interstitium to the cancer cells. Fibroblasts (connective tissue cells) are one of the most abundant non-malignant cells in tumors. They produce numerous collagen fibers. These fibers make tumors extremely dense and act as a physical barrier preventing drugs from penetrating the tumor interstitium.

Our method for overcoming obstacles to the delivery of drugs and natural compounds to cancer cells includes increasing tumor blood flow using ozone and hyperthermia; decreasing tumor interstitial fluid pressure using omega-3 fatty acids and bioavailable curcumin and epigallocatechin-3-gallate; and decreasing the density of tumor microenvironment using dasatinib and bioavailable resveratrol.

Dr. Daniel Thomas, DO, MS
Mount Dora, Florida, USA
Located in Mount Dora, Florida, Dr. Thomas is one of the most educated, experienced, and innovative physicians in North America. Over the past 30 years, he has helped people throughout the United States and Canada to prevent and overcome disease, improve their health, slow aging, and increase their lifespan. As an active translational researcher, Dr. Thomas has spent over 35,000 hours poring over the latest scientific discoveries and translating max. discoveries into promising theories


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