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Author Topic: Why Does Immunotherapy Fail So Often?  (Read 1867 times)

Offline danialthomas

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Why Does Immunotherapy Fail So Often?
« on: September 04, 2020, 05:28:38 pm »
Back in the early and mid-1990s, the development of modern cancer immunotherapy drugs was heralded as a new era in the treatment of cancer. It was thought that harnessing the power of the body’s immune system would be the ultimate way to fight cancer. It turns out that less than 25% of patients experience genuine benefit from immunotherapy. What went wrong? Why do most patients not experience the benefits of immunotherapy? It comes down to this: Having a “revved-up” immune system is not enough. Cancer has numerous immune-evasion mechanisms.
What allows cancer cells to escape immune attack despite receiving immunotherapy? The causes are numerous. Chief among them are: a) tumor microenvironment hypoxia and the resultant accumulation of hypoxia-inducible factor 1-alpha (HIF-1α); b) cancer-associated fibroblasts (CAFs); c) tumor-associated macrophages (TAMs); d) platelet-tumor cell interaction; e) composition of the gut microbiota; and f) accumulation of Activin A. If you are receiving immunotherapy, to increase its efficacy, please ask your oncologist to address the aforementioned issues.

Dr. Daniel Thomas, DO, MS
Mount Dora, Florida, USA
Located in Mount Dora, Florida, Dr. Thomas is one of the most educated, experienced, and innovative physicians in North America. Over the past 30 years, he has helped people throughout the United States and Canada to prevent and overcome disease, improve their health, slow aging, and increase their lifespan. As an active translational researcher, Dr. Thomas has spent over 35,000 hours poring over the latest scientific discoveries and translating max. discoveries into promising theories


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