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Author Topic: Cancer Immunotherapy Gets Assist From Micro-Scale Engineering  (Read 2058 times)

Offline Cancer Health Editors

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Cancer Immunotherapy Gets Assist From Micro-Scale Engineering
« on: January 23, 2020, 11:04:58 am »
Today’s cancer treatments can sometimes feel like yesterday’s science fiction. In 2017, the Food and Drug Administration approved two therapies that manipulate immune cells’ DNA to give them the power to hunt down and kill certain blood cancers. Scientists are working to extend this treatment strategy to as many cancer types as possible, including solid tumors like breast and pancreatic cancers. But solid tumors pose new challenges even to empowered immune cells, such as the sheer number of cancer cells found in one solid-tumor mass.

Matthias Stephan, MD, PhD, at Fred Hutchinson Cancer Research Center developed a patented strategy to deliver active, genetically engineered anti-cancer immune cells to solid tumors, dramatically improving their efficacy in mouse models of cancer. Now, he’s combined this science-fiction cancer treatment with a science-fiction material to improve it even further.

In a study published Dec. 9 in the journal Nature Biomedical Engineering, Stephan showed that loading genetically engineered immune cells onto a metal micromesh-based tumor stent can keep tumors from growing into and blocking the stent in a preclinical model of pancreatic cancer. He and his team also demonstrated that the micromesh can also deliver curative, standardized doses of anti-cancer immune cells to mice with inoperable ovarian cancer.

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