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Author Topic: Cancer Metabolism  (Read 386 times)

Offline danialthomas

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Cancer Metabolism
« on: December 08, 2019, 02:57:49 pm »
Metabolism is the process of converting food into energy. Cancer needs a lot of energy to enable its unabated growth and spread. Cancer cell metabolism differs from normal cells from which they are derived, conferring cancer with metabolic advantages (but also affording opportunities for therapeutic intervention). Cancer cells alter their metabolism to support rapid proliferation, continuous growth, survival in harsh conditions, invasion, metastasis, avoidance of immune attack, and resistance to chemotherapy and radiation.

Normal cells derive most of their energy from a process called oxidative phosphorylation—also known as respiration—which takes place in the mitochondria. Studies in the late 1920s conducted by German scientist Dr. Otto Warburg found that, even in the presence of oxygen, most cancer cells choose to metabolize glucose outside of the mitochondria by aerobic glycolysis—also known as fermentation. This is termed the Warburg Effect, and even though it is less efficient than oxidative phosphorylation, aerobic glycolysis produces needed energy quicker, helps generate nucleotides (building blocks needed for tumor cell proliferation), and inhibits immune attack by decreasing the expression of major histocompatibility complex-1 (MHC-1) and tumor-associated antigens (TAAs).

If faced with insufficient glucose, to ensure their survival, cancer cells can turn to “Plan B” and shift their metabolism to derive energy from the amino acid glutamine and/or fatty acids. Glucose, glutamine, and fatty acids are the primary fuels that drive all cancers. To weaken cancer, we are pioneering the use of diet, meal timing, natural compounds, and repurposed medicines to starve the cancer of the glucose, glutamine, and fatty acids it needs to grow and spread.

When backed into a corner from dietary glucose, glutamine, and fatty-acid deprivation, cancer cells can turn to “Plan C” and use protective autophagy as a last resort to ensure their survival. Also known as the Reverse Warburg Effect, this is a process where adjacent stromal (connective tissue) cells—also known as cancer-associated fibroblasts or CAFs—are autophagocytized (self-digested) to create energy-rich compounds, such as lactate and ketones, to feed hungry cancer cells. There is a growing body of evidence suggesting that the Reverse Warburg Effect may be the chief mechanism driving cancer cell metabolism. If this is the case, there are natural compounds and repurposed medicines that can “uncouple” cancer cells from their associated fibroblasts, block protective autophagy, and inhibit the Reverse Warburg Effect.

Dr. Daniel Thomas, DO, MS
Mount Dora, Florida

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« Last Edit: December 09, 2019, 08:59:11 am by Cancer Health Forum Moderators »
Located in Mount Dora, Florida, Dr. Thomas is one of the most educated, experienced, and innovative physicians in North America. Over the past 30 years, he has helped people throughout the United States and Canada to prevent and overcome disease, improve their health, slow aging, and increase their lifespan. As an active translational researcher, Dr. Thomas has spent over 35,000 hours poring over the latest scientific discoveries and translating max. discoveries into promising theories

 


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