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Welcome to the Cancer Health Forums, a round-the-clock discussion area for people who have any type of cancer, their friends and family and others with questions about living with cancer. Check in frequently to read what others have to say, post your comments, and hopefully learn more about how you can reach your own health goals.

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Messages - danialthomas

Pages: [1]
1
Cancer Research News & Studies / THE ROLE OF THE IMMUNE SYSTEM
« on: February 16, 2020, 03:53:53 pm »

An effective immune system can identify and destroy nascent (emerging) cancer cells in a process called immunosurveillance, which functions as our primary defense against cancer. Advancing age is associated with a decline in immunity, known as immunosenescence. Contributing factors include atrophy of the thymus gland and declining bone marrow activity, resulting in a reduction of functional cytotoxic T-cells (CTCs) and natural killer (NK) cells. Scientists found that a strong immune system, especially having ample and functional (immunocompetent) CTCs, may be the key to living a long and disease-free life (see https://www.pnas.org/content/pnas/early/2019/11/11/1907883116.full.pdf).

Integral to cancer prevention is a healthy (competent) immune system (see https://www.pnas.org/content/pnas/115/8/1883.full.pdf). Lack of CTC and NK cell activity impairs immunosurveillance and leads to an accumulation of cancer cells, cancer stem cells, and senescent cancer cells. Recent scientific studies have shown that by using repurposed medicines, peptides (short-chain proteins), and natural compounds, it may be possible to reverse immunosenescence by regenerating functional thymus tissue and boosting the production of CTCs and stimulating NK cell production in the bone marrow.

To learn more, visit newhopeforcancer.com

Dr. Daniel Thomas, DO, MS
Mount Dora, Florida


2
Cancer Research News & Studies / INTRAVENOUS VITAMIN C FOR CANCER
« on: February 09, 2020, 03:54:17 pm »
To target and kill the bulk (main) tumor cells along with the cancer stem cells, one treatment to consider is high-dose intravenous vitamin C (sodium ascorbate) augmented with oral copper, dasatinib, iron, and sulindac, and intravenous artesunate, azithromycin, doxycycline, calcium chloride, magnesium chloride, and potassium chloride.

Because of the unique bi-oxidant properties of vitamin C, at low (oral) doses, it works as a potent antioxidant that reduces oxidative stress. However, at high (intravenous) doses, vitamin C becomes a potent pro-oxidant “drug” that selectively induces severe oxidative stress in cancer cells through the formation of cytotoxic levels of hydrogen peroxide. Hydrogen peroxide is highly toxic to all cells; however, normal cells have higher levels of the enzyme catalase which neutralizes hydrogen peroxide. Cancer cells have up to 100 times less catalase than normal cells. The hydrogen peroxide produced by high-dose intravenous vitamin C cannot be fully neutralized by cancer cells.

There is a large volume of published studies documenting the use of intravenous vitamin C for cancer. Not only is there ample evidence that it is safe and effective when combined with conventional cancer treatment, there is also evidence that high-dose intravenous vitamin C can function as a stand-alone chemotherapeutic agent, killing cancer cells through the well-defined pro-oxidative, cytotoxic mechanism described above.

High-dose intravenous vitamin C targets many of the underlying pathologies that lead to the formation and spread of cancer. Preincubating the cancer cells with copper, dasatinib, iron, sulindac, and artesunate potentiates (amplifies) the pro-oxidative, cytotoxic, anti-cancer effects of vitamin C. The addition of azithromycin and doxycycline targets cancer stem cells. And the addition of calcium chloride, magnesium chloride, and potassium chloride prevents electrolyte imbalances during treatment.

Contraindications to treatment include any heart or kidney condition that can lead to fluid overload, G6PD deficiency, history of oxalate kidney stones, and severely elevated ferritin.


Dr. Daniel Thomas, DO, MS
Mount Dora, Florida

3
Cancer Research News & Studies / The Probelm Of Anemia
« on: February 02, 2020, 04:56:19 am »

Anemia (low hemoglobin) is a common problem in cancer patients. It is a result of the disease itself and/or bone-marrow suppression resulting from chemotherapy. Hypoxia is the chief consequence of anemia, a condition where insufficient oxygen makes it to the cells and tissues in the body. This can happen even when blood flow and oxygen saturation measurements are normal. Prolonged hypoxia stimulates the formation of hypoxia-inducible factor 1-alpha (HIF-1α). Accumula­tion of HIF-1α initiates a whole cascade of events that causes tumor cells to proliferate, including angiogenesis (growth of new blood vessels to nourish cancer cells).
Pro-oxidative, cytotoxic therapies, such as chemotherapy, radiation, and intravenous vitamin C are less effective under hypoxic conditions. Also, hypoxia can inhibit the anti-cancer activity of repurposed medicines. For example, under hypoxic conditions, metformin is unable to activate AMP-activated protein kinase (AMPK) and inhibit mammalian target of rapamycin (mTOR), which then prevents the inhibitory effects of metformin on tumor growth.
The vicious circle of hypoxia, disease progression and further anemia presents a challenge. We deal with this challenge by using natural compounds that have been shown to inhibit the formation of HIF-1α, even under hypoxic conditions. This results in slowed tumor cell growth and division. In cases of anemia, to sensitize tumor cells to the pro-oxidative, cytotoxic effect of intravenous vitamin C, we administer supplemental oxygen during treatment.
To learn more, visit newhopeforcancer.com

Dr. Daniel Thomas, DO, MS
Mount Dora, Florida

4
Cancer Research News & Studies / SENESCENT CANCER CELLS
« on: January 26, 2020, 03:02:06 pm »
Sharing some important knowledge with you all.

Besides cancer stem cells, the other problematic cells are senescent cancer cells. Not all cancer cells can be forced into apoptosis (programmed cell death) when treated with conventional and/or alternative therapy. Instead of dying, some cancer cells will simply stop dividing and multiplying and enter a senescent or dormant-like state. This is called senescence-associated growth arrest (SAGA), and while it sounds good, it is accompanied by something not so good called senescence-associated secretory phenotype (SASP) in which there is overactive secretion of pro-inflammatory, cancer-promoting compounds by the senescent cancer cells.
It is good that senescent cancer cells don’t divide and multiply like regular cancer cells, however, because senescent cancer cells don’t die, they retain their dysfunctional cellular metabolism and secrete pro-inflammatory, cancer-promoting compounds. If too many senescent cancer cells accumulate and the immune system doesn’t kill enough of them, this can lead to further growth and spread of cancer. Because cancer patients are usually immunosuppressed due to disease and/or treatment, we are pioneering the use of repurposed medicines and natural compounds that have been shown to target senescent cells by directly killing them and/or curbing the effects of SASP. To learn more, visit newhopeforcancer.com

Dr. Daniel Thomas, DO, MS
Mount Dora, Florida

5
Cancer Research News & Studies / Cancer Stem Cells
« on: January 17, 2020, 03:20:10 pm »
In the human body, there are healthy stem cells that help repair and regenerate damaged tissues. Similarly, in tumors, there are cancer stem cells (CSCs) that help repair and regenerate tumors. This subset of cancer cells is also known as tumor-survival cells (TSCs) or tumor-initiating cells (TICs). Many experts believe that successful eradication of CSCs could change the face of cancer treatment. Not only are CSCs the main driver of distant metastasis, treatment failure, and disease recurrence, CSCs may also be the root cause of the original tumor itself. Because of the powerful survival mechanisms of CSCs, chemotherapy, radiation, and surgery are unable to kill them. In fact, conventional therapy can do the exact opposite and stimulate the proliferation and virulence of CSCs.

CSCs can migrate and nest in various areas of the body and remain dormant for months, years, or even decades until the right stimulus comes along and awakens them. While conventional therapy can eradicate the bulk (main) tumor cells, sooner or later, lingering CSCs can form new and often more aggressive tumors from a small number of cells (as few as 100). In other words, being “tumor-free” is not the same as being “cancer-free.” Eradicating the bulk tumor cells is not enough. CSCs must also be eradicated to achieve long-term survival. At present, there are no drugs that are FDA-approved to specifically target CSCs. To address this urgent and unmet need, we are pioneering the use of repurposed medicines and natural compounds that have been shown to target CSCs by killing them and/or preventing them from entering a dormant and more resistant state.

Dr. Daniel Thomas, DO, MS
Mount Dora, Florida

Links removed by moderator

6
Cancer Research News & Studies / Resolving Inflammation
« on: January 10, 2020, 04:49:20 pm »
Chronic inflammation is a major contributor to the development and spread of cancer. Most cancer patients have elevated levels of inflammatory blood markers, such as C-reactive protein, homocysteine, and fibrinogen, as well as outward symptoms like persistent pain. Resolving cancer-promoting inflammation is crucial and should a central component of any anti-cancer protocol. Natural compounds like curcumin can inhibit the initiation of inflammation and may reduce its severity, but they do not resolve ongoing inflammation. The latter requires unique fatty-acid derived compounds known as specialized pro-resolving mediators or SPMs. SPMs facilitate the removal of dead and dying cells and cellular debris left over from inflammation. SPMs help restore an appropriate balance between pro- and anti-inflammatory mediators. And SPMs initiate and promote regeneration of tissues that have been damaged by inflammation.

Dr. Daniel Thomas, DO, MS
Mount Dora, Florida

Link removed by moderator

7
Cancer Research News & Studies / Repairing The Left Over Damage
« on: January 08, 2020, 03:37:04 pm »
Studies have shown that conventional cancer treatment can accelerate the aging process, leading to fatigue, decline in brain function, heart disease, and a return of cancer. Long after treatment has been completed, chemotherapy and radiation can leave considerable damage to the heart, lungs, brain, nerves, kidneys, urinary bladder, liver, intestines, bone marrow, immune system, muscles, and reproductive organs. This can permanently affect your quality of life and shorten your life. This is an area that nobody seems to be addressing. Because of the urgent and unmet need, we are pioneering the use of repurposed medicines, peptides, and natural compounds to help repair tissue damage and restore quality of life.

Dr. Daniel Thomas, DO, MS
Mount Dora, Florida

Links removed by moderator

8
Living with Brain Cancer / Glioblastoma-Specific Application
« on: December 25, 2019, 02:45:36 pm »
For those suffering from glioblastoma, or for those with a loved one suffering from glioblastoma, to help improve overall survival, in addition to using a combination of medicines to deprive cancer of the nutrients it needs to grow and spread, here is what we have been using that has glioblastoma-specific application:

•   Curcumin
•   Epicatechin gallate
•   Gallium maltolate
•   Perillyl alcohol
•   Hydrogen gas
•   Pregnenolone
•   Resveratrol
•   Siberian rhubarb
•   Syrosingopine
•   Valganciclovir

Dr. Daniel Thomas, DO, MS
Mount Dora, Florida

Links removed by moderator

9
Cancer Research News & Studies / Cancer Metabolism
« on: December 08, 2019, 02:57:49 pm »
Metabolism is the process of converting food into energy. Cancer needs a lot of energy to enable its unabated growth and spread. Cancer cell metabolism differs from normal cells from which they are derived, conferring cancer with metabolic advantages (but also affording opportunities for therapeutic intervention). Cancer cells alter their metabolism to support rapid proliferation, continuous growth, survival in harsh conditions, invasion, metastasis, avoidance of immune attack, and resistance to chemotherapy and radiation.

Normal cells derive most of their energy from a process called oxidative phosphorylation—also known as respiration—which takes place in the mitochondria. Studies in the late 1920s conducted by German scientist Dr. Otto Warburg found that, even in the presence of oxygen, most cancer cells choose to metabolize glucose outside of the mitochondria by aerobic glycolysis—also known as fermentation. This is termed the Warburg Effect, and even though it is less efficient than oxidative phosphorylation, aerobic glycolysis produces needed energy quicker, helps generate nucleotides (building blocks needed for tumor cell proliferation), and inhibits immune attack by decreasing the expression of major histocompatibility complex-1 (MHC-1) and tumor-associated antigens (TAAs).

If faced with insufficient glucose, to ensure their survival, cancer cells can turn to “Plan B” and shift their metabolism to derive energy from the amino acid glutamine and/or fatty acids. Glucose, glutamine, and fatty acids are the primary fuels that drive all cancers. To weaken cancer, we are pioneering the use of diet, meal timing, natural compounds, and repurposed medicines to starve the cancer of the glucose, glutamine, and fatty acids it needs to grow and spread.

When backed into a corner from dietary glucose, glutamine, and fatty-acid deprivation, cancer cells can turn to “Plan C” and use protective autophagy as a last resort to ensure their survival. Also known as the Reverse Warburg Effect, this is a process where adjacent stromal (connective tissue) cells—also known as cancer-associated fibroblasts or CAFs—are autophagocytized (self-digested) to create energy-rich compounds, such as lactate and ketones, to feed hungry cancer cells. There is a growing body of evidence suggesting that the Reverse Warburg Effect may be the chief mechanism driving cancer cell metabolism. If this is the case, there are natural compounds and repurposed medicines that can “uncouple” cancer cells from their associated fibroblasts, block protective autophagy, and inhibit the Reverse Warburg Effect.

Dr. Daniel Thomas, DO, MS
Mount Dora, Florida

Links removed by moderator

10
Cancer Research News & Studies / Preventing Cancer Recurrence
« on: November 29, 2019, 02:56:40 pm »
PREVENTING CANCER RECURRENCE

Cancer doesn’t happen overnight nor by random chance. Cancer should be considered a wake-up call because it often results from years of eating a nutritionally deficient diet and poor lifestyle habits that create a cancer-friendly cellular environment of hypoxia, acidosis, hyponutrition, and inflammation.

A growing body of evidence supports the hypothesis that cancer is closely associated with accelerated aging, and by slowing the aging process, you may prevent the onset or recurrence of cancer and other chronic diseases. Slowing aging centers around changes in diet and lifestyle to improve mitochondrial function; promote effective immunity; increase microcirculation and tissue oxygenation; promote tissue alkalinity; enhance detoxification; improve gut health; reduce oxidative stress, inflammation, and exposure to environmental toxins; and promote sound sleep, physical fitness, and good mental health.

THE ROLE OF THE IMMUNE SYSTEM

An effective immune system can identify and destroy nascent (emerging) cancer cells in a process called immunosurveillance, which functions as our primary defense against cancer. Advancing age is associated with a decline in immunity, known as immunosenescence. Contributing factors include atrophy of the thymus gland and declining bone marrow activity, resulting in a reduction of functional cytotoxic T-cells (CTCs) and natural killer (NK) cells. Scientists found that a strong immune system, especially having ample and functional (immunocompetent) CTCs, may hold the key to longevity.

The key to cancer prevention lies in a healthy (competent) immune system. Lack of CTC and NK cell activity impairs immunosurveillance and leads to an accumulation of cancer cells, cancer stem cells, and senescent cancer cells. Recent scientific studies have shown that by using repurposed medicines, peptides, and plant-derived compounds, it may now be possible to reverse immunosenescence by regenerating functional thymus tissue and boosting the production of CTCs and stimulating NK cell production in the bone marrow.

Dr. Daniel Thomas, DO, MS

Links removed by moderator

11
Cancer Research News & Studies / Immunometabolism Research
« on: November 17, 2019, 05:01:37 pm »
Over the past decade, “immunometabolism” has become one of the most exciting areas of scientific research. Immunometabolism is an emerging field that investigates the interaction between immunologic and metabolic processes. Interest in this field is gaining momentum due to the realization that metabolism plays a central role in immune responses in healthy individuals and lack of proper immune response in those with cancer. This important discovery has validated our decade-long approach that was designed to starve tumor cells and spur immune cells to attack the tumor.

Another exciting area of scientific research is immunosurveillance restoration. An effective immune system can identify and destroy nascent (emerging) cancer cells in a process called immunosurveillance, which functions as our primary defense against cancer. Advancing age is associated with a decline in adaptive and innate immunity, known as immunosenescence. Contributing factors include atrophy of the thymus gland and declining bone marrow activity, resulting in a reduction of cytotoxic T-cells (CTCs) and natural killer (NK) cells. This impairs immunosurveillance and leads to an accumulation of cancer cells, cancer stem cells, and senescent cancer cells. Using a combination of repurposed medicines, peptides (short-chain proteins), and plant-derived compounds, we have found it possible to reverse immunosenescence by regenerating functional thymus tissue and boosting the production of CTCs and boosting NK cell production in the bone marrow.

Dr. Daniel Thomas, DO, MS
Mount Dora, Florida, USA

Links removed by moderator

12
Cancer is a serious and terrifying disease. If you have been diagnosed with cancer, your mind is probably filled with fear, worry, and questions. Therefore, it is extremely important to talk openly and frankly with your oncologist. To better understand your disease and your treatment options, it is imperative to ask the right questions. If you are determined to beat cancer, here are the top 10 questions you need to ask your oncologist:

1. What is the rationale for your recommended treatment and is your expectation curative (achieving long-term remission) or palliative (only improving quality of life)?
2. What are the likely side effects of treatment and how will you deal with each of them?
3. How do you plan to prevent damage to the DNA and mitochondria of my normal (healthy) cells?
4. Treatment resistance, systemic toxicity, and immunosuppression are leading causes of treatment failure and subsequent mortality. What is your plan to overcome these challenges if they occur?
5. How many of the following hallmarks of cancer will you be targeting: a) Genetic instability, b) sustained proliferation, c) replicative immortality, d) dysregulated metabolism, e) evading growth suppressors, f) resisting cell death, g) tumor-promoting inflammation, h) angiogenesis, i) tissue invasion and metastasis, and j) immune evasion?
6. Cancer stem cells are thought to be a root cause of cancer metastasis, treatment resistance, and disease recurrence. What will you be doing to target my cancer stem cells since chemotherapy, radiation, and surgery do not target these cells and can, in fact, stimulate them to proliferate and spread?
7. What will you be doing to strengthen my immune system to help fight cancer?
8. Studies have shown that a significant percentage of cancer cases have their roots in diet and lifestyle. Also, chemotherapy and radiation can lead to nutritional deficiencies. To address these issues, what diet, lifestyle, and nutritional supplements do you recommend that may improve my treatment outcome?
9. What might my overall survival time be if I follow your recommendations compared to not following your recommendations?
10. Are you knowledgeable about alternative cancer treatments? If not, are you willing to work with physicians with expertise in integrative cancer therapies that can exploit the metabolic deficiencies of cancer cells and sensitize them to conventional therapy; provide nutritional support; enhance immunity; reduce the risk of cancer metastasis and recurrence, and help improve overall survival and quality of life?
 
The above questions will help you prepare for your appointment so you will come away from the visit with the crucial information you need to move forward and fight cancer properly. Do not be afraid to ask these questions. Your health and very life may be on the line, so insist on complete answers from your oncologist. Ask a friend or family member to accompany you as a second set of eyes and ears to listen to what the doctor says. And be sure to take notes for later reference.
 
Note: It is important to have your eyes wide open as you move forward, so please be aware that the oncologist may not be current in his or her understanding of cancer cell biology, what causes cancer, and how to prevent its recurrence. The oncologist may not be informed about the crucial role that nutrition plays in fighting cancer, may mock the idea of changing your diet and lifestyle, and may be dismissive of anything outside of conventional therapy. For many cancers, conventional therapy alone may not be enough. There are complementary and alternative treatments you should be aware of.
 
Dr. Daniel Thomas, DO, MS

Links removed by moderator

13
Cancer Research News & Studies / The Problem Of Anemia
« on: October 06, 2019, 06:59:16 pm »
Anemia (low hemoglobin) is a common problem in cancer patients. It is a result of the disease itself and/or bone-marrow suppression resulting from chemotherapy. Hypoxia is the chief consequence of anemia, a condition where insufficient oxygen makes it to the cells and tissues in the body. This can happen even when blood flow and oxygen saturation measurements are normal. Prolonged hypoxia stimulates the formation of hypoxia-inducible factor 1-alpha (HIF-1α). Accumulation of HIF-1α initiates a whole cascade of events that causes tumor cells to proliferate, including angiogenesis (growth of new blood vessels to nourish cancer cells).
 
Pro-oxidative, cytotoxic therapies, such as chemotherapy, radiation, and intravenous vitamin C are less effective under hypoxic conditions. Also, hypoxia can inhibit the anti-cancer activity of repurposed drugs. For example, under hypoxic conditions, metformin is unable to activate AMP-activated protein kinase (AMPK) and inhibit mammalian target of rapamycin (mTOR), which then prevents the inhibitory effects of metformin on tumor growth.
 
The vicious circle of hypoxia, disease progression and further anemia presents a challenge. We deal with this challenge by using targeted plant-derived compounds that have been shown to inhibit the formation of HIF-1α, even under hypoxic conditions. This results in slowed tumor cell growth and division. In cases of anemia, to sensitize tumor cells to the pro-oxidative, cytotoxic effect of intravenous vitamin C, we administer supplemental oxygen during treatment.

Dr. Daniel Thomas, DO, MS

Links removed by moderator

14
Cancer Research News & Studies / Cancer Metabolism
« on: September 24, 2019, 07:53:18 pm »
Recent scientific discoveries have led to an update in the theory of what causes cancer. Contrary to the old “genomic” theory that cancer is caused by DNA mutations in the nucleus of a cell (nuclear DNA), the new “metabolic” theory of cancer holds that cancer’s deadly path begins in the mitochondria where cells generate energy. Mutations in nuclear DNA are involved, but they are likely secondary to or a consequence of defects in the energy-producing mitochondria. Under this theory, cancer is a metabolic disease and the tumor is a “symptom.” Thus, to treat cancer more effectively, you must target the one weakness that is common to virtually all cancers. That common weakness is damaged mitochondria resulting in altered metabolism.
 
Cancer needs a steady source of energy and molecular building blocks to produce more cancer cells. Normal cells obtain most of their energy from a process called oxidative phosphorylation, also known as respiration. Cancer cells, on the other hand, switch their metabolism to obtain most of their energy from glucose (sugar) in a process called aerobic glycolysis, also known as the Warburg Effect or fermentation, as the byproduct is lactic acid. The Warburg Effect exposes a fundamental weakness of cancer cells which is their reliance on excess glucose for survival and maximal proliferation. It has been observed in numerous experiments and has inspired treatments that target tumor growth by depriving cancer cells of glucose.
 
If faced with insufficient glucose, to ensure their survival, cancer cells can often turn to “Plan B” and switch their metabolism to derive energy from the amino acid glutamine and/or fatty acids. Glucose, glutamine, and fatty acids are the primary fuels that drive most cancers. To starve and weaken cancer, we are pioneering the use of diet, meal timing, plant-derived compounds, and repurposed drugs to deprive cancer of the glucose, glutamine, and fatty acids it needs to grow and spread.
 
When backed into a corner from glucose, glutamine, and fatty acid deprivation, some cancer cells can turn to “Plan C” and use protective autophagy as a last resort to ensure their survival. Also known as the Reverse Warburg Effect, this is a process where weaker cancer cells and surrounding normal cells are partially “digested” to create energy-rich metabolites, including pyruvate and lactate that can be used to feed hungry cancer cells. Fortunately, there are repurposed drugs have been shown to inhibit protective autophagy.

Dr. Daniel Thomas, DO, MS

Links removed by moderator

15
Cancer Research News & Studies / Solution For Targeting Cancer Cells
« on: August 01, 2019, 07:16:45 pm »
PROBLEM: Not all cancer cells can be induced to undergo apoptosis (programmed cell death). Even when they do, the mere act of apoptosis can trigger the proliferation of cancer stem cells. Cancer stem cells can lead to distant metastasis, treatment failure, and disease recurrence.

SOLUTION: Target the cancer stem cells by directly killing them and/or preventing them from entering a dormant and more resistant state.

PROBLEM: Instead of apoptosis, some cancer cells can be induced to enter a senescent or dormant state. Fortunately, senescent cancer cells permanently stop dividing, but unfortunately, they don’t die. They maintain cellular metabolism. This metabolism leads to the secretion of pro-inflammatory, cancer-causing compounds (also known as the “senescent secretome”). If enough senescent cancer cells accumulate, this can induce further growth and spread of cancer.

SOLUTION: Target accumulated senescent cancer stem cells by directly killing them and/or keep the senescence secretome under control.

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