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Welcome to the Cancer Health Forums, a round-the-clock discussion area for people who have any type of cancer, their friends and family and others with questions about living with cancer. Check in frequently to read what others have to say, post your comments, and hopefully learn more about how you can reach your own health goals.

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Messages - danialthomas

Pages: [1] 2
1

Cases of COVID-19 (coronavirus disease of 2019) continue to rise in the United States. Please do not minimize the impact this virus can have, even in young people (see https://www.propublica.org/article/a-medical-worker-describes--terrifying-lung-failure-from-covid19-even-in-his-young-patients).

Based on recent data (see https://www.newsweek.com/hydroxychloroquine-coronavirus-conventional-care-study-1494176), I am no longer prescribing hydroxychloroquine to my patients. I am now prescribing nitazoxanide as an alternative (see https://www.nature.com/articles/s41422-020-0282-0.pdf).

Like me, I am sure you have gotten unsolicited emails talking about using supplements to “strengthen your immune system” considering COVID-19. I’m all in favor of a strong immune system, but that may not be enough when you have a virus that can DISABLE the immune system. In my professional medical opinion, you need a protocol that can simultaneously: a) kill COVID-19, b) block the ability of the virus to inhibit the immune system, c) limit the cytokine storm, and d) inhibit lung damage. To learn more, visit https://www.thomashealthblog.com/?p=10115.

Please note that lack of time prevents me from answering any questions you may have from this posting. This information is being posted to help protect you and your family.

Dr. Daniel Thomas, DO, MS
Mount Dora, Florida
http://www.newhopeforcancer.com

2
I have been treating challenging stage-4 cancer patients using an immunometabolic approach for 32 years. In that period of time, I have seen these eight signs and symptoms often show up in people who are less able to achieve remission:

1.   Moderate-to-severe cachexia (weight loss, muscle loss, lack of appetite, fatigue, and decreased strength)
2.   Moderate-to-severe ascites (fluid in the abdomen) or pleural effusion (fluid between the lungs and chest wall)
3.   Uncontrollable pain and/or nausea
4.   Markedly elevated iron in the blood (ferritin >300)
5.   Markedly elevated inflammatory markers (hs-CRP >3, homocysteine >16, fibrinogen >500)
6.   Severe anemia (hemoglobin <8)
7.   Hypoalbuminemia (blood albumin level below the reference range)
8.   Low heart-rate variability

Having any of the above signs and symptoms does not preclude me from treating a patient, but it does make my job more difficult. Bottom line, if you have been diagnosed with cancer, please do not wait until you develop any of these signs and symptoms. Be sure to check out all your treatment options with your oncologist along with a local integrative/functional-medicine doctor. The best outcomes are usually obtained when you combine (integrate) the best of Western medicine with the best of alternative medicine.

Dr. Daniel Thomas, DO, MS
newhopeforcancer.com
victoriousovercancer.com

3
Off Topic Forum / Confession
« on: February 23, 2020, 04:51:40 pm »
I post messages to various cancer groups/forums like this from time to time, not to seek patients (my practice is already full), but rather, to educate the public and other doctors. I have been treating cancer immunometabolically for 32 years. During this time, I have gained a lot of valuable insight and experience.
Dr. Daniel Thomas, DO, MS

4
Cancer Research News & Studies / AGING AND CANCER
« on: February 23, 2020, 04:47:51 pm »
Increasing age is the most significant risk factor for the development of cancer, but why? Chronological aging may enable the growth of tumors through the onset of cell-cycle arrest (senescence) of aging fibroblasts, which makes them prone to autophagy. Senescence-induced autophagy creates a tissue microenvironment conducive to the growth of cancer via the production of high-energy mitochondrial fuels from fibroblasts (such as lactate) that can feed nascent (emerging) cancer cells. Furthermore, senescent fibroblasts can promote tumor initiation, growth, and spread through the production of inflammation-signaling molecules. To help prevent the onset or recurrence of cancer, we are pioneering the use of repurposed medicines, peptides, and natural compounds to eradicate aged, autophagy-prone, senescent fibroblasts.

To learn more about the role that fibroblasts play in cancer, visit https://www.thomashealthblog.com/?p=9688
Dr. Daniel Thomas, DO, MS
Mount Dora, Florida
newhopeforcancer.com

5
Cancer Research News & Studies / THE ROLE OF THE IMMUNE SYSTEM
« on: February 16, 2020, 03:53:53 pm »

An effective immune system can identify and destroy nascent (emerging) cancer cells in a process called immunosurveillance, which functions as our primary defense against cancer. Advancing age is associated with a decline in immunity, known as immunosenescence. Contributing factors include atrophy of the thymus gland and declining bone marrow activity, resulting in a reduction of functional cytotoxic T-cells (CTCs) and natural killer (NK) cells. Scientists found that a strong immune system, especially having ample and functional (immunocompetent) CTCs, may be the key to living a long and disease-free life (see https://www.pnas.org/content/pnas/early/2019/11/11/1907883116.full.pdf).

Integral to cancer prevention is a healthy (competent) immune system (see https://www.pnas.org/content/pnas/115/8/1883.full.pdf). Lack of CTC and NK cell activity impairs immunosurveillance and leads to an accumulation of cancer cells, cancer stem cells, and senescent cancer cells. Recent scientific studies have shown that by using repurposed medicines, peptides (short-chain proteins), and natural compounds, it may be possible to reverse immunosenescence by regenerating functional thymus tissue and boosting the production of CTCs and stimulating NK cell production in the bone marrow.

To learn more, visit newhopeforcancer.com

Dr. Daniel Thomas, DO, MS
Mount Dora, Florida


6
Cancer Research News & Studies / INTRAVENOUS VITAMIN C FOR CANCER
« on: February 09, 2020, 03:54:17 pm »
To target and kill the bulk (main) tumor cells along with the cancer stem cells, one treatment to consider is high-dose intravenous vitamin C (sodium ascorbate) augmented with oral copper, dasatinib, iron, and sulindac, and intravenous artesunate, azithromycin, doxycycline, calcium chloride, magnesium chloride, and potassium chloride.

Because of the unique bi-oxidant properties of vitamin C, at low (oral) doses, it works as a potent antioxidant that reduces oxidative stress. However, at high (intravenous) doses, vitamin C becomes a potent pro-oxidant “drug” that selectively induces severe oxidative stress in cancer cells through the formation of cytotoxic levels of hydrogen peroxide. Hydrogen peroxide is highly toxic to all cells; however, normal cells have higher levels of the enzyme catalase which neutralizes hydrogen peroxide. Cancer cells have up to 100 times less catalase than normal cells. The hydrogen peroxide produced by high-dose intravenous vitamin C cannot be fully neutralized by cancer cells.

There is a large volume of published studies documenting the use of intravenous vitamin C for cancer. Not only is there ample evidence that it is safe and effective when combined with conventional cancer treatment, there is also evidence that high-dose intravenous vitamin C can function as a stand-alone chemotherapeutic agent, killing cancer cells through the well-defined pro-oxidative, cytotoxic mechanism described above.

High-dose intravenous vitamin C targets many of the underlying pathologies that lead to the formation and spread of cancer. Preincubating the cancer cells with copper, dasatinib, iron, sulindac, and artesunate potentiates (amplifies) the pro-oxidative, cytotoxic, anti-cancer effects of vitamin C. The addition of azithromycin and doxycycline targets cancer stem cells. And the addition of calcium chloride, magnesium chloride, and potassium chloride prevents electrolyte imbalances during treatment.

Contraindications to treatment include any heart or kidney condition that can lead to fluid overload, G6PD deficiency, history of oxalate kidney stones, and severely elevated ferritin.


Dr. Daniel Thomas, DO, MS
Mount Dora, Florida

7
Cancer Research News & Studies / The Probelm Of Anemia
« on: February 02, 2020, 04:56:19 am »

Anemia (low hemoglobin) is a common problem in cancer patients. It is a result of the disease itself and/or bone-marrow suppression resulting from chemotherapy. Hypoxia is the chief consequence of anemia, a condition where insufficient oxygen makes it to the cells and tissues in the body. This can happen even when blood flow and oxygen saturation measurements are normal. Prolonged hypoxia stimulates the formation of hypoxia-inducible factor 1-alpha (HIF-1α). Accumula­tion of HIF-1α initiates a whole cascade of events that causes tumor cells to proliferate, including angiogenesis (growth of new blood vessels to nourish cancer cells).
Pro-oxidative, cytotoxic therapies, such as chemotherapy, radiation, and intravenous vitamin C are less effective under hypoxic conditions. Also, hypoxia can inhibit the anti-cancer activity of repurposed medicines. For example, under hypoxic conditions, metformin is unable to activate AMP-activated protein kinase (AMPK) and inhibit mammalian target of rapamycin (mTOR), which then prevents the inhibitory effects of metformin on tumor growth.
The vicious circle of hypoxia, disease progression and further anemia presents a challenge. We deal with this challenge by using natural compounds that have been shown to inhibit the formation of HIF-1α, even under hypoxic conditions. This results in slowed tumor cell growth and division. In cases of anemia, to sensitize tumor cells to the pro-oxidative, cytotoxic effect of intravenous vitamin C, we administer supplemental oxygen during treatment.
To learn more, visit newhopeforcancer.com

Dr. Daniel Thomas, DO, MS
Mount Dora, Florida

8
Cancer Research News & Studies / SENESCENT CANCER CELLS
« on: January 26, 2020, 03:02:06 pm »
Sharing some important knowledge with you all.

Besides cancer stem cells, the other problematic cells are senescent cancer cells. Not all cancer cells can be forced into apoptosis (programmed cell death) when treated with conventional and/or alternative therapy. Instead of dying, some cancer cells will simply stop dividing and multiplying and enter a senescent or dormant-like state. This is called senescence-associated growth arrest (SAGA), and while it sounds good, it is accompanied by something not so good called senescence-associated secretory phenotype (SASP) in which there is overactive secretion of pro-inflammatory, cancer-promoting compounds by the senescent cancer cells.
It is good that senescent cancer cells don’t divide and multiply like regular cancer cells, however, because senescent cancer cells don’t die, they retain their dysfunctional cellular metabolism and secrete pro-inflammatory, cancer-promoting compounds. If too many senescent cancer cells accumulate and the immune system doesn’t kill enough of them, this can lead to further growth and spread of cancer. Because cancer patients are usually immunosuppressed due to disease and/or treatment, we are pioneering the use of repurposed medicines and natural compounds that have been shown to target senescent cells by directly killing them and/or curbing the effects of SASP. To learn more, visit newhopeforcancer.com

Dr. Daniel Thomas, DO, MS
Mount Dora, Florida

9
Cancer Research News & Studies / Cancer Stem Cells
« on: January 17, 2020, 03:20:10 pm »
In the human body, there are healthy stem cells that help repair and regenerate damaged tissues. Similarly, in tumors, there are cancer stem cells (CSCs) that help repair and regenerate tumors. This subset of cancer cells is also known as tumor-survival cells (TSCs) or tumor-initiating cells (TICs). Many experts believe that successful eradication of CSCs could change the face of cancer treatment. Not only are CSCs the main driver of distant metastasis, treatment failure, and disease recurrence, CSCs may also be the root cause of the original tumor itself. Because of the powerful survival mechanisms of CSCs, chemotherapy, radiation, and surgery are unable to kill them. In fact, conventional therapy can do the exact opposite and stimulate the proliferation and virulence of CSCs.

CSCs can migrate and nest in various areas of the body and remain dormant for months, years, or even decades until the right stimulus comes along and awakens them. While conventional therapy can eradicate the bulk (main) tumor cells, sooner or later, lingering CSCs can form new and often more aggressive tumors from a small number of cells (as few as 100). In other words, being “tumor-free” is not the same as being “cancer-free.” Eradicating the bulk tumor cells is not enough. CSCs must also be eradicated to achieve long-term survival. At present, there are no drugs that are FDA-approved to specifically target CSCs. To address this urgent and unmet need, we are pioneering the use of repurposed medicines and natural compounds that have been shown to target CSCs by killing them and/or preventing them from entering a dormant and more resistant state.

Dr. Daniel Thomas, DO, MS
Mount Dora, Florida

Links removed by moderator

10
Cancer Research News & Studies / Resolving Inflammation
« on: January 10, 2020, 04:49:20 pm »
Chronic inflammation is a major contributor to the development and spread of cancer. Most cancer patients have elevated levels of inflammatory blood markers, such as C-reactive protein, homocysteine, and fibrinogen, as well as outward symptoms like persistent pain. Resolving cancer-promoting inflammation is crucial and should a central component of any anti-cancer protocol. Natural compounds like curcumin can inhibit the initiation of inflammation and may reduce its severity, but they do not resolve ongoing inflammation. The latter requires unique fatty-acid derived compounds known as specialized pro-resolving mediators or SPMs. SPMs facilitate the removal of dead and dying cells and cellular debris left over from inflammation. SPMs help restore an appropriate balance between pro- and anti-inflammatory mediators. And SPMs initiate and promote regeneration of tissues that have been damaged by inflammation.

Dr. Daniel Thomas, DO, MS
Mount Dora, Florida

Link removed by moderator

11
Cancer Research News & Studies / Repairing The Left Over Damage
« on: January 08, 2020, 03:37:04 pm »
Studies have shown that conventional cancer treatment can accelerate the aging process, leading to fatigue, decline in brain function, heart disease, and a return of cancer. Long after treatment has been completed, chemotherapy and radiation can leave considerable damage to the heart, lungs, brain, nerves, kidneys, urinary bladder, liver, intestines, bone marrow, immune system, muscles, and reproductive organs. This can permanently affect your quality of life and shorten your life. This is an area that nobody seems to be addressing. Because of the urgent and unmet need, we are pioneering the use of repurposed medicines, peptides, and natural compounds to help repair tissue damage and restore quality of life.

Dr. Daniel Thomas, DO, MS
Mount Dora, Florida

Links removed by moderator

12
Living with Brain Cancer / Glioblastoma-Specific Application
« on: December 25, 2019, 02:45:36 pm »
For those suffering from glioblastoma, or for those with a loved one suffering from glioblastoma, to help improve overall survival, in addition to using a combination of medicines to deprive cancer of the nutrients it needs to grow and spread, here is what we have been using that has glioblastoma-specific application:

•   Curcumin
•   Epicatechin gallate
•   Gallium maltolate
•   Perillyl alcohol
•   Hydrogen gas
•   Pregnenolone
•   Resveratrol
•   Siberian rhubarb
•   Syrosingopine
•   Valganciclovir

Dr. Daniel Thomas, DO, MS
Mount Dora, Florida

Links removed by moderator

13
Cancer Research News & Studies / Cancer Metabolism
« on: December 08, 2019, 02:57:49 pm »
Metabolism is the process of converting food into energy. Cancer needs a lot of energy to enable its unabated growth and spread. Cancer cell metabolism differs from normal cells from which they are derived, conferring cancer with metabolic advantages (but also affording opportunities for therapeutic intervention). Cancer cells alter their metabolism to support rapid proliferation, continuous growth, survival in harsh conditions, invasion, metastasis, avoidance of immune attack, and resistance to chemotherapy and radiation.

Normal cells derive most of their energy from a process called oxidative phosphorylation—also known as respiration—which takes place in the mitochondria. Studies in the late 1920s conducted by German scientist Dr. Otto Warburg found that, even in the presence of oxygen, most cancer cells choose to metabolize glucose outside of the mitochondria by aerobic glycolysis—also known as fermentation. This is termed the Warburg Effect, and even though it is less efficient than oxidative phosphorylation, aerobic glycolysis produces needed energy quicker, helps generate nucleotides (building blocks needed for tumor cell proliferation), and inhibits immune attack by decreasing the expression of major histocompatibility complex-1 (MHC-1) and tumor-associated antigens (TAAs).

If faced with insufficient glucose, to ensure their survival, cancer cells can turn to “Plan B” and shift their metabolism to derive energy from the amino acid glutamine and/or fatty acids. Glucose, glutamine, and fatty acids are the primary fuels that drive all cancers. To weaken cancer, we are pioneering the use of diet, meal timing, natural compounds, and repurposed medicines to starve the cancer of the glucose, glutamine, and fatty acids it needs to grow and spread.

When backed into a corner from dietary glucose, glutamine, and fatty-acid deprivation, cancer cells can turn to “Plan C” and use protective autophagy as a last resort to ensure their survival. Also known as the Reverse Warburg Effect, this is a process where adjacent stromal (connective tissue) cells—also known as cancer-associated fibroblasts or CAFs—are autophagocytized (self-digested) to create energy-rich compounds, such as lactate and ketones, to feed hungry cancer cells. There is a growing body of evidence suggesting that the Reverse Warburg Effect may be the chief mechanism driving cancer cell metabolism. If this is the case, there are natural compounds and repurposed medicines that can “uncouple” cancer cells from their associated fibroblasts, block protective autophagy, and inhibit the Reverse Warburg Effect.

Dr. Daniel Thomas, DO, MS
Mount Dora, Florida

Links removed by moderator

14
Cancer Research News & Studies / Preventing Cancer Recurrence
« on: November 29, 2019, 02:56:40 pm »
PREVENTING CANCER RECURRENCE

Cancer doesn’t happen overnight nor by random chance. Cancer should be considered a wake-up call because it often results from years of eating a nutritionally deficient diet and poor lifestyle habits that create a cancer-friendly cellular environment of hypoxia, acidosis, hyponutrition, and inflammation.

A growing body of evidence supports the hypothesis that cancer is closely associated with accelerated aging, and by slowing the aging process, you may prevent the onset or recurrence of cancer and other chronic diseases. Slowing aging centers around changes in diet and lifestyle to improve mitochondrial function; promote effective immunity; increase microcirculation and tissue oxygenation; promote tissue alkalinity; enhance detoxification; improve gut health; reduce oxidative stress, inflammation, and exposure to environmental toxins; and promote sound sleep, physical fitness, and good mental health.

THE ROLE OF THE IMMUNE SYSTEM

An effective immune system can identify and destroy nascent (emerging) cancer cells in a process called immunosurveillance, which functions as our primary defense against cancer. Advancing age is associated with a decline in immunity, known as immunosenescence. Contributing factors include atrophy of the thymus gland and declining bone marrow activity, resulting in a reduction of functional cytotoxic T-cells (CTCs) and natural killer (NK) cells. Scientists found that a strong immune system, especially having ample and functional (immunocompetent) CTCs, may hold the key to longevity.

The key to cancer prevention lies in a healthy (competent) immune system. Lack of CTC and NK cell activity impairs immunosurveillance and leads to an accumulation of cancer cells, cancer stem cells, and senescent cancer cells. Recent scientific studies have shown that by using repurposed medicines, peptides, and plant-derived compounds, it may now be possible to reverse immunosenescence by regenerating functional thymus tissue and boosting the production of CTCs and stimulating NK cell production in the bone marrow.

Dr. Daniel Thomas, DO, MS

Links removed by moderator

15
Cancer Research News & Studies / Immunometabolism Research
« on: November 17, 2019, 05:01:37 pm »
Over the past decade, “immunometabolism” has become one of the most exciting areas of scientific research. Immunometabolism is an emerging field that investigates the interaction between immunologic and metabolic processes. Interest in this field is gaining momentum due to the realization that metabolism plays a central role in immune responses in healthy individuals and lack of proper immune response in those with cancer. This important discovery has validated our decade-long approach that was designed to starve tumor cells and spur immune cells to attack the tumor.

Another exciting area of scientific research is immunosurveillance restoration. An effective immune system can identify and destroy nascent (emerging) cancer cells in a process called immunosurveillance, which functions as our primary defense against cancer. Advancing age is associated with a decline in adaptive and innate immunity, known as immunosenescence. Contributing factors include atrophy of the thymus gland and declining bone marrow activity, resulting in a reduction of cytotoxic T-cells (CTCs) and natural killer (NK) cells. This impairs immunosurveillance and leads to an accumulation of cancer cells, cancer stem cells, and senescent cancer cells. Using a combination of repurposed medicines, peptides (short-chain proteins), and plant-derived compounds, we have found it possible to reverse immunosenescence by regenerating functional thymus tissue and boosting the production of CTCs and boosting NK cell production in the bone marrow.

Dr. Daniel Thomas, DO, MS
Mount Dora, Florida, USA

Links removed by moderator

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