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Cancer Health Main Forums => Cancer Research News & Studies => Topic started by: danialthomas on October 11, 2021, 03:51:44 pm

Title: Lithium
Post by: danialthomas on October 11, 2021, 03:51:44 pm
To help induce iron-mediated death of cancer cells (ferroptosis), besides blocking the ferroptosis-inhibiting carbonic anhydrase #9 (CAIX) protein, it is important to target the lymphatic system. Cancer cells often metastasize regionally through the lymphatic system before they metastasize systemically through the bloodstream. Exposure to lymph fluid has been found to protect cancer cells from ferroptosis and increase their ability to survive during subsequent metastasis through the blood. Differences between lymph fluid and blood plasma that may contribute to this include higher levels of glutathione and oleic acid and less iron in lymph fluid.

To help suppress the metastatic potential of cancer cells via the lymphatic system and promote ferroptosis, lithium has been found to:

a) decrease lymphatic density and surface contact with cancer cells
b) inhibit the migration of cancer cells to the lymphatic system
c) decrease lymphatic permeability, thereby inhibiting cancer cells from entering or exiting the lymphatic system.

Dr. Daniel Thomas, DO, MS
Mount Dora, Florida

References:

1. Chafe S, Vizeacoumar F, Venkateswaran G, Nemirovsky O, Awrey S, et.al. Genome-wide synthetic lethal screen unveils novel CAIX-NFS1/xCT axis as a targetable vulnerability in hypoxic solid tumors. Science Advances. 27 Aug 2021: Vol. 7, No. 35, eabj0364.
2. Ubellacker JM, Tasdogan A, Ramesh V, Shen B, Mitchell EC, Martin-Sandoval MS, Gu Z, McCormick ML, Durham AB, Spitz DR, Zhao Z, Mathews TP, Morrison SJ. Lymph protects metastasizing melanoma cells from ferroptosis. Nature. 2020 Sep;585(7823):113-118.
3. Maeng YS, Lee R, Lee B, Choi SI, Kim EK. Lithium inhibits tumor lymphangiogenesis and metastasis through the inhibition of TGFBIp expression in cancer cells. Sci Rep. 2016 Feb 9;6:20739.

Disclaimer:

This information is for educational purposes only and not intended or implied to be a substitute for professional medical advice, diagnosis, treatment, and monitoring by your doctor. Therefore, I cannot answer questions regarding appropriateness in your situation nor give treatment advice. That is for your doctor to determine after he or she carefully studies the references above.