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Cancer Health Main Forums => Cancer Research News & Studies => Topic started by: danialthomas on October 06, 2021, 06:12:29 pm

Title: Targeting Tumor Hypoxia
Post by: danialthomas on October 06, 2021, 06:12:29 pm
As a tumor grows, it soon outstrips its blood supply, necessitating the formation of new blood vessels to continue to deliver oxygen and nutrients to the tumor. To orchestrate this, cancer cells boost the production of growth factors such as VEGF (vascular endothelial growth factor) to stimulate the formation of blood vessels in a process known as angiogenesis. Unlike the carefully formed and functional blood vessels in healthy tissue, tumor blood vessels tend to be malformed and dysfunctional. As a result, blood flow in tumors is non-uniform and erratic. Some regions of the tumor will be non-hypoxic (sufficiently oxygenated), whereas other regions will be hypoxic (oxygen-deprived).

One of the main reasons that people die prematurely of late-stage cancer is treatment failure due to treatment resistance. It turns out, tumor hypoxia plays a central role in limiting the effectiveness of anti-cancer therapy. Tumor hypoxia stimulates the formation of and stabilizes (activates) hypoxia-inducible factor 1-alpha (HIF-1α). Accumulation of stabilized HIF-1α promotes a whole cascade of events that promote the proliferation and survival of cancer cells and cancer stem cells, tumor invasion, metastasis, immunosuppression, drug resistance, ferroptosis resistance, and disease recurrence. To combat this, we have the following tools at our disposal to help reverse tumor hypoxia and its effects, and improve treatment outcomes:

• Acetazolamide
• Carbogen breathing
• Curcumin
• Hyperthermia
• Intravenous ozonated saline
• Pentoxifylline
• Sulforaphane
• Transdermal carbon dioxide

Dr. Daniel Thomas, DO, MS
Mount Dora, Florida


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This information is for educational purposes only and not intended or implied to be a substitute for professional medical advice, diagnosis, treatment, and monitoring by your doctor. Therefore, I cannot answer questions regarding appropriateness in your situation nor give treatment advice. That is for your doctor to determine after he or she carefully studies the references above