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Cancer Health Main Forums => Cancer Research News & Studies => Topic started by: danialthomas on September 19, 2021, 03:52:37 pm

Title: The Origins Of Cancer
Post by: danialthomas on September 19, 2021, 03:52:37 pm
Like evolution vs. creation and the origins of life, there are two competing theories regarding the origins of cancer: Genetic mutation and metabolic dysfunction. Which of these is correct? It turns out, both are correct, and iron is at the very center. Iron dysregulation unifies the concepts embodied in both the genetic and metabolic theories of cancer.

Something called the intracellular labile iron pool (LIP) acts as a central hub in the birth of cancer and links iron metabolism to the traditional cancer hallmarks. Increases in the LIP creates reactive oxygen species (ROS) which in turn induces mitochondrial (metabolic) dysfunction. Increases in the LIP simultaneously induces genomic instability. At the end of the day, iron may be the single-most important “bad guy” that needs to be dealt with.

Due to the higher rates of proliferation and DNA synthesis in cancer cells vs. normal cells, cancer cells have greater requirements for and contain much more iron than normal cells. The extra iron is also needed, ironically, by cancer’s DNA repair pathways, enabling it to survive DNA damage induced by chemotherapeutic treatment.

So, while all this information may be fascinating, where do you go from here? How do you turn cancer’s love of iron into its worst nightmare? If you’re talking about the prevention of cancer, my suggestion is to keep your ferritin level between 30 and 50 ng/mL if you’re a woman and 50 and 75 ng/mL if you’re a man. When talking about the treatment of cancer, my suggestion is to use compounds shown to induce ferroptosis (iron-mediated cell death) and block ferroptosis-resistance as described in my previous posting.

Being a type of programmed or regulated necrosis of cells, ferroptosis has an advantage over apoptosis of being more immunogenic. Due to the release of immune-attracting damage-associated molecular patterns (DAMPs), ferroptosis recruits and activates immune cells at tumor sites. This can be enhanced by using natural compounds shown to increase the activity of dendritic cells, cytotoxic T-lymphocytes, B-lymphocytes, Natural Killer cells, and phagocytic macrophages. This too was described in my previous posting.

Dr. Daniel Thomas, DO, MS
Mount Dora, Florida

Reference:
Petronek MS, Spitz DR, Buettner GR, Allen BG. Linking Cancer Metabolic Dysfunction and Genetic Instability through the Lens of Iron Metabolism. Cancers (Basel). 2019;11(8):1077.

Disclaimer:

This information is for educational purposes only and not intended or implied to be a substitute for professional medical advice, diagnosis, treatment, and monitoring by your doctor. Therefore, I cannot answer questions regarding appropriateness in your situation nor give treatment advice. That is for your doctor to determine after he or she carefully studies the reference above and the information in my previous posting.