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Cancer Health Main Forums => Cancer Research News & Studies => Topic started by: danialthomas on September 07, 2021, 04:07:01 pm

Title: How To Reduce Pill-Burden When Treating Cancer
Post by: danialthomas on September 07, 2021, 04:07:01 pm
Over the past 34 years, I have found that “less is more” when it comes to treating cancer. Taking too many pills not only causes nausea, vomiting, and ruined appetite, but it can also put undue burden on kidney and liver function, as well as impair bone-marrow production of blood cells.

When treating cancer, it is important that these 7 areas be included:

1. Decrease intratumoral hypoxia
2. Inhibit glucose, glutamine, and fatty-acid metabolism
3. Sensitize cancer cells to oxidative stress
4. Disable cancer’s glutathione and thioredoxin antioxidant defense systems
5. Induce apoptosis through excessive oxidative stress
6. Increase tumor-infiltrating lymphocytes and natural-killer cells
7. Promote removal of tumor debris by increasing resolvins

To keep the pill-burden low, we can accomplish the above by using the 12 items below:

1. 2-deoxy-D-glucose
2. Aspirin
3. Bromelain
4. Ganoderma lucidum
5. Molecular iodine
6. Piperlongumine
7. Propranolol
8. Pro-resolving mediators
9. Pyrroloquinoline quinone
10. Sodium selenite
11. Tocotrienols
12. Transcutaneous carbon dioxide

If you are taking a lot of pills and wish to take fewer, I encourage you to share this information with your oncologist and/or integrative/functional-medicine doctor.
Dr. Daniel Thomas, DO, MS
Mount Dora, Florida

References:
1. Brohée L, Peulen O, Nusgens B, Castronovo V, Thiry M, Colige AC, Deroanne CF. Propranolol sensitizes prostate cancer cells to glucose metabolism inhibition and prevents cancer progression. Sci Rep. 2018 May 4;8(1):7050.
2. Chang CJ, Chen YY, Lu CC, Lin CS, Martel J, Tsai SH, Ko YF, Huang TT, Ojcius DM, Young JD, Lai HC. Ganoderma lucidum stimulates NK cell cytotoxicity by inducing NKG2D/NCR activation and secretion of perforin and granulysin. Innate Immun. 2014 Apr;20(3):301-11.
3. Chang TC, Wei PL, Makondi PT, Chen WT, Huang CY, Chang YJ. Bromelain inhibits the ability of colorectal cancer cells to proliferate via activation of ROS production and autophagy. PLoS One. 2019 Jan 18;14(1):e0210274.
4. Gilligan MM, Gartung A, Sulciner ML, et al. Aspirin-triggered proresolving mediators stimulate resolution in cancer. Proc Natl Acad Sci U S A. 2019;116(13):6292-6297.
5. Kieliszek M, Lipinski B, Błażejak S. Application of Sodium Selenite in the Prevention and Treatment of Cancers. Cells. 2017 Oct 24;6(4):39.
6. Min Z, Wang L, Jin J, et al. Pyrroloquinoline Quinone Induces Cancer Cell Apoptosis via Mitochondrial-Dependent Pathway and Down-Regulating Cellular Bcl-2 Protein Expression. J Cancer. 2014;5(7):609-624.
7. Mojadadi, Shafi et al. Immunomodulatory Effects of Ganoderma lucidum (W. Curt.:Fr.) P. Karst. (Aphyllophoromycetideae) on CD4+/CD8+ Tumor Infiltrating Lymphocytes in Breast-Cancer-Bearing Mice. International Journal of Medicinal Mushrooms8 (2006): 315-320.
8. Moreno-Vega A, Vega-Riveroll L, Ayala T, et al. Adjuvant Effect of Molecular Iodine in Conventional Chemotherapy for Breast Cancer. Randomized Pilot Study. Nutrients. 2019;11(7):1623.
9. Shutt DC, O’Dorisio MS, Aykin-Burns N, Spitz DR. 2-deoxy-D-glucose induces oxidative stress and cell killing in human neuroblastoma cells. Cancer Biol Ther.2010;9(11):853-861.
10. Takeda D, Hasegawa T, Ueha T, Imai Y, Sakakibara A, Minoda M, Kawamoto T, Minamikawa T, Shibuya Y, Akisue T, Sakai Y, Kurosaka M, Komori T. Transcutaneous carbon dioxide induces mitochondrial apoptosis and suppresses metastasis of oral squamous cell carcinoma in vivo. PLoS One. 2014 Jul 2;9(7):e100530.
11. Tham SY, Loh HS, Mai CW, Fu JY. Tocotrienols Modulate a Life or Death Decision in Cancers. Int J Mol Sci. 2019;20(2):372.
12. Wang H, Jiang H, Corbet C, de Mey S, Law K, Gevaert T, Feron O, De Ridder M. Piperlongumine increases sensitivity of colorectal cancer cells to radiation: Involvement of ROS production via dual inhibition of glutathione and thioredoxin systems. Cancer Lett. 2019 May 28;450:42-52.
13. Zhang Q, Zhu B, Li Y. Resolution of Cancer-Promoting Inflammation: A New Approach for Anticancer Therapy. Front Immunol. 2017 Feb 2;8:71.
14. Zhao J, Zhou R, Hui K, et al. Selenite inhibits glutamine metabolism and induces apoptosis by regulating GLS1 protein degradation via APC/C-CDH1 pathway in colorectal cancer cells. Oncotarget. 2017;8(12):18832-18847.

Disclaimer:
This information is for educational purposes only and not intended or implied to be a substitute for professional medical advice, diagnosis, treatment, and monitoring by your personal physician. Therefore, I cannot answer questions regarding appropriateness in your situation, nor give brand names, dosages, or treatment instructions. That is for your personal physician to determine after her or she carefully studies the references above.