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Cancer Health Main Forums => Cancer Research News & Studies => Topic started by: danialthomas on August 31, 2021, 06:46:03 pm

Title: Iron Removal Enhances Intravenous Vitamin C-Induced Apoptosis Of Cancer Cells
Post by: danialthomas on August 31, 2021, 06:46:03 pm
High blood levels of the extracellular iron-storage protein called ferritin correlate with aggressive disease and poorer clinical outcomes in cancer patients. Excess extracellular iron has been found to diminish the anti-cancer effects of intravenous vitamin C (IVC). Based on this, administering IVC without considering ferritin levels is ill-advised. Excess extracellular iron decreases the intracellular uptake of vitamin C and IVC-induced production of cancer-killing, pro-oxidative hydrogen peroxide. Removal of extracellular iron using the iron-chelating drug Deferasirox was shown to improve the anti-cancer effects of IVC by promoting intracellular uptake of vitamin C and IVC-induced production of hydrogen peroxide.

Dr. Daniel Thomas, DO, MS
Mount Dora, Florida

Reference:
Tsuma-Kaneko, M., Sawanobori, M., Kawakami, S. et al. Iron removal enhances vitamin C-induced apoptosis and growth inhibition of K-562 leukemic cells. Sci Rep 8, 17377 (2018).

Disclaimer:
This information is for educational purposes only. It is not intended or implied to be a substitute for professional medical advice, diagnosis, treatment, and monitoring by your personal physician. Therefore, I cannot comment as to appropriateness in your situation, nor give dosages or treatment guidelines. That is for your personal physician to determine after studying the reference above