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Cancer Health Main Forums => Cancer Research News & Studies => Topic started by: danialthomas on August 25, 2021, 03:25:13 pm

Title: Is There Such A Thing As Stage 1 Or Stage 2 Cancer
Post by: danialthomas on August 25, 2021, 03:25:13 pm
New research suggests that many colorectal cancers spread from the site where they first developed to other parts of the body long before the original tumor can be detected by current diagnostic tests.
We have long assumed that the spread (metastasis) of tumors occurs later in the disease process. As tumors grow and cancer cells accrue more genetic mutations, some cells develop the ability to move from the site of the primary tumor into the bloodstream or lymphatic system to spread to distant locations in the body, and grow into tumors in the new locations.
Dr. Christina Curtis from Stanford University’s School of Medicine and her team used genetic analysis of the primary colorectal tumors and the metastatic tumors from the same patients, coupled with computer simulations. The findings led them to conclude that colorectal cancer can spread soon after the original tumor appears, and likely does so years before the disease is every diagnosed. Their findings show that some cancers are capable of metastasizing right from the start.
Does this important discovery apply to cancers other than colorectal? We do not know yet, but I suspect that will be the case. To be safe, if you have been told that you have non-metastatic (stage-1 or stage-2) cancer, and you insist on doing “localized” treatment only, such as surgery or radiation, you may wish to reconsider and follow up with systemic treatment.

Comments from Dr. Thomas: Please note that this information for educational purposes only. It is not intended or implied to be a substitute for professional medical advice, diagnosis, treatment, and monitoring by your personal physician. Therefore, I cannot give specific treatment recommendations. That is for your personal physician to determine after studying the reference below.

Dr. Daniel Thomas, DO, MS
Mount Dora, Florida

Reference:
Hu Z, Ding J, Ma Z, Sun R, Seoane JA, Scott Shaffer J, Suarez CJ, Berghoff AS, Cremolini C, Falcone A, Loupakis F, Birner P, Preusser M, Lenz HJ, Curtis C. Quantitative evidence for early metastatic seeding in colorectal cancer. Nat Genet. 2019 Jul;51(7):1113-1122.