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Cancer Health Main Forums => Cancer Research News & Studies => Topic started by: danialthomas on July 28, 2021, 09:36:47 am

Title: Beyond Intravenous Vitamin C
Post by: danialthomas on July 28, 2021, 09:36:47 am
We know from published research that a high concentration of curcumin (turmeric extract) is effective at killing cancer cells without harming normal cells. In addition, a 5-micromolar concentration of curcumin has been found to reduce the amount of cisplatin (chemotherapy drug) needed to kill various types of cancer cells by a remarkable 300-fold.

When synergistic curcumin and low-dose cisplatin are administered as intravenous cyclodextrin-based nanoparticles, the efficacy of curcumin and cisplatin is improved even further by increasing their solubility, stability, and penetration into tumors. Further synergy is achieved by adding intravenous dichloroacetate, oral celecoxib, and hyperthermia:

• By raising the internal temperature of tumors to 43°C with medical electromagnetic hyperthermia, we sensitize cancer cells to the effects of curcumin and cisplatin and increase tumor blood flow to deliver more curcumin, cisplatin, dichloroacetate, and celecoxib deep into tumors.
• Dichloroacetate sensitizes cancer cells to the effects of hyperthermia and cisplatin.
• Curcumin sensitizes cancer cells to dichloroacetate.
• Celecoxib sensitizes cancer cells to the effects of curcumin, cisplatin, and dichloroacetate.
• Cancer cells and cancer stem cells are directly killed in the presence of sufficient heat.
• Hyperthermia triggers a potent immune response by improving immune recognition of cancer cells through the expression of heat-shock proteins (HSPs) and increasing tumor-infiltrating lymphocytes (TILs). The latter can be further enhanced with the use of oral molecular iodine and/or injectable thymosin alpha 1 (Tα1).

Please note that this information for educational purposes only. It is not intended or implied to be a substitute for professional medical advice, diagnosis, treatment, and monitoring by your personal physician. Therefore, I cannot give dosages or treatment guidelines for the above-mentioned items. That is for your personal physician to determine after studying the references below.

Dr. Daniel Thomas, DO, MS
Mount Dora, Florida

References:
Cheng Y, Weng S, Yu L, Zhu N, Yang M, Yuan Y. The Role of Hyperthermia in the Multidisciplinary Treatment of Malignant Tumors. Integr Cancer Ther. 2019;18:1534735419876345.
Costantini C, Bellet MM, Pariano M, et al. A Reappraisal of Thymosin Alpha1 in Cancer Therapy. Front Oncol. 2019;9:873.
Huang H, Yu K, Mohammadi A, Karanthanasis E, Godley A, Yu JS. It’s Getting Hot in Here: Targeting Cancer Stem-like Cells with Hyperthermia. J Stem Cell Transplant Biol. 2017;2(2):113.
Kan PC, Chang YJ, Chien CS, Su CY, Fang HW. Coupling Dichloroacetate Treatment with Curcumin Significantly Enhances Anticancer Potential. Anticancer Res. 2018 Nov;38(11):6253-6261.
Lev-Ari S, Strier L, Kazanov D, Madar-Shapiro L, Dvory-Sobol H, Pinchuk I, Marian B, Lichtenberg D, Arber N. Celecoxib and curcumin synergistically inhibit the growth of colorectal cancer cells. Clin Cancer Res. 2005 Sep 15;11(18):6738-44.
Li B, Li X, Xiong H, et al. Inhibition of COX2 enhances the chemosensitivity of dichloroacetate in cervical cancer cells. Oncotarget. 2017;8(31):51748-51757.
Liu B, Yan S, Qu L, Zhu J. Celecoxib enhances anticancer effect of cisplatin and induces anoikis in osteosarcoma via PI3K/Akt pathway. Cancer Cell Int. 2017;17:1.
McCubrey JA, Abrams SL, Lertpiriyapong K, Cocco L, Ratti S, Martelli AM, Candido S, Libra M, Murata RM, Rosalen PL, Lombardi P, Montalto G, Cervello M, Gizak A, Rakus D, Steelman LS. Effects of berberine, curcumin, resveratrol alone and in combination with chemotherapeutic drugs and signal transduction inhibitors on cancer cells-Power of nutraceuticals. Adv Biol Regul. 2018 Jan;67:190-211.
Moreno-Vega A, Vega-Riveroll L, Ayala T, et al. Adjuvant Effect of Molecular Iodine in Conventional Chemotherapy for Breast Cancer. Randomized Pilot Study. Nutrients. 2019;11(7):1623.
Muñoz, N.M., Minhaj, A.A., Guo, C., Michael, C., & Cressman, E. (2016). Metabolic modulation with dichloroacetate sensitizes cells to hyperthermia in human hepatocellular carcinoma cell lines. Journal of Vascular and Interventional Radiology, 27.
Qiu, N., Li, X. & Liu, J. Application of cyclodextrins in cancer treatment. J Incl Phenom Macrocycl Chem 89, 229–246 (2017).
Olszewski U, Poulsen TT, Ulsperger E, Poulsen HS, Geissler K, Hamilton G. In vitro cytotoxicity of combinations of dichloroacetate with anticancer platinum compounds. Clin Pharmacol. 2010;2:177-83.
Ralph SJ, Nozuhur S, Moreno-Sánchez R, Rodríguez-Enríquez S, Pritchard R. NSAID celecoxib: a potent mitochondrial pro-oxidant cytotoxic agent sensitizing metastatic cancers and cancer stem cells to chemotherapy. J Cancer Metastasis Treat 2018;4:49.
Syng-Ai C, Kumari AL, Khar A. Effect of curcumin on normal and tumor cells: role of glutathione and bcl-2. Mol Cancer Ther. 2004 Sep;3(9):1101-8.
Yagawa Y, Tanigawa K, Kobayashi Y, Yamamoto M. Cancer immunity and therapy using hyperthermia with immunotherapy, radiotherapy, chemotherapy, and surgery. J Cancer Metastasis Treat 2017;3:218-230.
Zhang Q, Zhu B, Li Y. Resolution of Cancer-Promoting Inflammation: A New Approach for Anticancer Therapy. Front Immunol. 2017 Feb 2;8:71.