Cancer Health Forums

Cancer Health Main Forums => Cancer Research News & Studies => Topic started by: danialthomas on June 30, 2021, 06:17:37 pm

Title: Oxidizing Cancer Cells To Death
Post by: danialthomas on June 30, 2021, 06:17:37 pm
Cancer cells are particularly prone to oxidative stress because they are more active than normal cells, their mitochondria are often dysfunctional, and tumors possess abnormal vascular networks resulting in unstable oxygen delivery. Most conventional anti-cancer treatments, such as chemotherapy and radiation, kill cancer cells by severe oxidative stress by inducing the production of excessive reactive oxygen species (ROS). It turns out, immune cells also utilize severe oxidative stress to kill cancer cells.
Oxidative stress upregulates numerous survival mechanisms of cancer and allows tumors to grow and spread and enables them to resist the effects of treatment and evade immune attack. Oxidative stress is a double-edged sword, however, and cancer cells have their limit. The way to push cancer cells past their limit and induce apoptosis (cell death), is to impair their antioxidant defense system by depleting their stores of glutathione and thioredoxin reductase—cancer’s two main antioxidants that neutralize oxidative stress and prevent irreversible cellular oxidative damage. By depleting these antioxidants, we sensitize cancer to the deadly effects of oxidative stress by exceeding the capacity of its protective antioxidant defense system and push the oxidative insult to the point where, instead of enabling cancer cells to thrive, it now results in their death.
By using the supplements and repurposed medications below, we can kill cancer cells by sensitizing tumors to oxidative stress, inducing cytotoxic levels of oxidative stress, dually inhibiting the glutathione and thioredoxin systems, arresting the cancer cell cycle, and improving the immune response. We also impair glucose, glutamine, and fatty acid metabolism of tumors, as well as protective autophagy, all while keeping the “pill burden” relatively low.

• 2-deoxy-D-glucose
• Artemisinin
• Auranofin
• Disulfiram
• Docosahexaenoic acid
• Mebendazole
• Propranolol
• Sodium selenite

Dr. Daniel Thomas, DO, MS
Mount Dora, Florida

For More Information:
Beatty A, Singh T, Tyurina YY, Tyurin VA, Samovich S, Nicolas E, Maslar K, Zhou Y, Cai KQ, Tan Y, Doll S, Conrad M, Subramanian A, Bayır H, Kagan VE, Rennefahrt U, Peterson JR. Ferroptotic cell death triggered by conjugated linolenic acids is mediated by ACSL1. Nat Commun. 2021 Apr 14;12(1):2244.
Brohée L, Peulen O, Nusgens B, Castronovo V, Thiry M, Colige AC, Deroanne CF. Propranolol sensitizes prostate cancer cells to glucose metabolism inhibition and prevents cancer progression. Sci Rep. 2018 May 4;8(1):7050.
Brüning A, Kast RE. Oxidizing to death: disulfiram for cancer cell killing. Cell Cycle. 2014;13(10):1513-4.
Guerini AE, Triggiani L, Maddalo M, Bonù ML, Frassine F, Baiguini A, Alghisi A, Tomasini D, Borghetti P, Pasinetti N, Bresciani R, Magrini SM, Buglione M. Mebendazole as a Candidate for Drug Repurposing in Oncology: An Extensive Review of Current Literature. Cancers (Basel). 2019 Aug 31;11(9):1284.
Kieliszek M, Lipinski B, Błażejak S. Application of Sodium Selenite in the Prevention and Treatment of Cancers. Cells. 2017 Oct 24;6(4):39.
Onodera T, Momose I, Kawada M. Potential Anticancer Activity of Auranofin. Chem Pharm Bull (Tokyo). 2019;67(3):186-191.
Shutt DC, O'Dorisio MS, Aykin-Burns N, Spitz DR. 2-deoxy-D-glucose induces oxidative stress and cell killing in human neuroblastoma cells. Cancer Biol Ther. 2010;9(11):853-861.
Waseem Y, Hasan CA, Ahmed F. Artemisinin: A Promising Adjunct for Cancer Therapy. Cureus. 2018 Nov 23;10(11):e3628.
Zhao J, Zhou R, Hui K, et al. Selenite inhibits glutamine metabolism and induces apoptosis by regulating GLS1 protein degradation via APC/C-CDH1 pathway in colorectal cancer cells. Oncotarget. 2017;8(12):18832-18847.

This information for educational purposes only. It is not intended or implied to be a substitute for professional medical advice, diagnosis, treatment, and monitoring by your personal physician. Therefore, Dr. Thomas cannot give dosages for the above-mentioned medications. That is for your personal physician to determine after studying the references shown above.