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Cancer Health Main Forums => Cancer Research News & Studies => Topic started by: danialthomas on February 23, 2020, 04:47:51 pm

Post by: danialthomas on February 23, 2020, 04:47:51 pm
Increasing age is the most significant risk factor for the development of cancer, but why? Chronological aging may enable the growth of tumors through the onset of cell-cycle arrest (senescence) of aging fibroblasts, which makes them prone to autophagy. Senescence-induced autophagy creates a tissue microenvironment conducive to the growth of cancer via the production of high-energy mitochondrial fuels from fibroblasts (such as lactate) that can feed nascent (emerging) cancer cells. Furthermore, senescent fibroblasts can promote tumor initiation, growth, and spread through the production of inflammation-signaling molecules. To help prevent the onset or recurrence of cancer, we are pioneering the use of repurposed medicines, peptides, and natural compounds to eradicate aged, autophagy-prone, senescent fibroblasts.

To learn more about the role that fibroblasts play in cancer, visit
Dr. Daniel Thomas, DO, MS
Mount Dora, Florida