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Cancer Health Main Forums => Cancer Research News & Studies => Topic started by: danialthomas on September 24, 2019, 07:53:18 pm

Title: Cancer Metabolism
Post by: danialthomas on September 24, 2019, 07:53:18 pm
Recent scientific discoveries have led to an update in the theory of what causes cancer. Contrary to the old “genomic” theory that cancer is caused by DNA mutations in the nucleus of a cell (nuclear DNA), the new “metabolic” theory of cancer holds that cancer’s deadly path begins in the mitochondria where cells generate energy. Mutations in nuclear DNA are involved, but they are likely secondary to or a consequence of defects in the energy-producing mitochondria. Under this theory, cancer is a metabolic disease and the tumor is a “symptom.” Thus, to treat cancer more effectively, you must target the one weakness that is common to virtually all cancers. That common weakness is damaged mitochondria resulting in altered metabolism.
 
Cancer needs a steady source of energy and molecular building blocks to produce more cancer cells. Normal cells obtain most of their energy from a process called oxidative phosphorylation, also known as respiration. Cancer cells, on the other hand, switch their metabolism to obtain most of their energy from glucose (sugar) in a process called aerobic glycolysis, also known as the Warburg Effect or fermentation, as the byproduct is lactic acid. The Warburg Effect exposes a fundamental weakness of cancer cells which is their reliance on excess glucose for survival and maximal proliferation. It has been observed in numerous experiments and has inspired treatments that target tumor growth by depriving cancer cells of glucose.
 
If faced with insufficient glucose, to ensure their survival, cancer cells can often turn to “Plan B” and switch their metabolism to derive energy from the amino acid glutamine and/or fatty acids. Glucose, glutamine, and fatty acids are the primary fuels that drive most cancers. To starve and weaken cancer, we are pioneering the use of diet, meal timing, plant-derived compounds, and repurposed drugs to deprive cancer of the glucose, glutamine, and fatty acids it needs to grow and spread.
 
When backed into a corner from glucose, glutamine, and fatty acid deprivation, some cancer cells can turn to “Plan C” and use protective autophagy as a last resort to ensure their survival. Also known as the Reverse Warburg Effect, this is a process where weaker cancer cells and surrounding normal cells are partially “digested” to create energy-rich metabolites, including pyruvate and lactate that can be used to feed hungry cancer cells. Fortunately, there are repurposed drugs have been shown to inhibit protective autophagy.

Dr. Daniel Thomas, DO, MS

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