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Liver Cancer Forums => Living with Liver Cancer => Topic started by: iana5252 on June 07, 2019, 09:34:54 am

Title: Checkpoint Immunotherapies Show Promise for Liver Cancer
Post by: iana5252 on June 07, 2019, 09:34:54 am
This news came out of ASCO, a big cancer doctor gathering in Chicago held in June every year. Here's some of Cancer Health's coverage of the news.

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The PD-1 checkpoint inhibitor Keytruda (pembrolizumab) offered improved response rates for people with advanced liver cancer, although survival improvements did not meet statistical thresholds, according to research presented at the American Society of Clinical Oncology (ASCO) annual meeting this week in Chicago. Another study showed that pairing Opdivo (nivolumab) with a different type of immunotherapy improved outcomes considerably.

Hepatocellular carcinoma (HCC), the most common type of cancer that originates in the liver, is often detected late and is difficult to treat. Liver cancer generally does not respond well to traditional chemotherapy. Keytruda and Opdivo, as well as a handful of targeted therapies that interfere with cell growth and blood vessel development, have recently been approved to treat this cancer.

Keytruda and Opdivo are PD-1 checkpoint inhibitors that help the immune system fight cancer. PD-1, a checkpoint protein on T cells, helps regulate immune function. Some tumors can hijack PD-1 to turn off immune responses against them. Drugs that block the interaction between PD-1 and its binding partner, known as PD-L1, can release the brakes and restore T-cell activity. Yervoy is a different type of checkpoint inhibitor that blocks CTLA-4, which turns off immune responses by suppressing T-cell replication.

Read more...
https://www.cancerhealth.com/article/checkpoint-immunotherapies-liver-cancer