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Colon Cancer Forums => Living with Colon Cancer => Topic started by: iana5252 on June 07, 2019, 09:32:41 am

Title: An experimental therapy shows promise for colon cancer
Post by: iana5252 on June 07, 2019, 09:32:41 am
This news came out of ASCO, a big cancer doctor gathering in Chicago held in June every year. Here's some of Cancer Health's coverage of the news.

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An experimental therapy designed to target mutated KRAS proteins showed good activity in a small Phase I study of people with lung cancer, colon cancer and other solid tumors, researchers reported this week at the American Society of Clinical Oncology (ASCO) annual meeting in Chicago.

If these results are confirmed in larger trials, this could be good news for patients because KRAS mutations occur more frequently in lung tumors than other mutations—such as ALK, BRAF and EGFR—targeted by existing drugs. Likewise, only a small proportion of colorectal cancer is targetable by existing medications.

Researchers have identified several so-called driver mutations that contribute to the development of cancer. Mutations involving KRAS, a signaling protein that regulates cell multiplication, are the most common genetic variations in lung cancer. But to date, no medications have been able to successfully target these mutations.

“KRAS has been a target of active exploration in cancer research since it was identified as one of the first oncogenes more than 30 years ago, but it remained undruggable due to a lack of traditional small molecule binding pockets on the protein,” David Reese, MD, executive vice president of research and development at Amgen, said in a company press release. “AMG 510 seeks to crack the KRAS code by exploiting a previously hidden groove on the protein surface.”

Read more...
https://www.cancerhealth.com/article/first-kras-targeted-therapy-shows-promise-lung-colon-cancer